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Earth BioGenome Project: Sequencing life for the future of life.

Publication ,  Journal Article
Lewin, HA; Robinson, GE; Kress, WJ; Baker, WJ; Coddington, J; Crandall, KA; Durbin, R; Edwards, SV; Forest, F; Gilbert, MTP; Goldstein, MM ...
Published in: Proceedings of the National Academy of Sciences of the United States of America
April 2018

Increasing our understanding of Earth's biodiversity and responsibly stewarding its resources are among the most crucial scientific and social challenges of the new millennium. These challenges require fundamental new knowledge of the organization, evolution, functions, and interactions among millions of the planet's organisms. Herein, we present a perspective on the Earth BioGenome Project (EBP), a moonshot for biology that aims to sequence, catalog, and characterize the genomes of all of Earth's eukaryotic biodiversity over a period of 10 years. The outcomes of the EBP will inform a broad range of major issues facing humanity, such as the impact of climate change on biodiversity, the conservation of endangered species and ecosystems, and the preservation and enhancement of ecosystem services. We describe hurdles that the project faces, including data-sharing policies that ensure a permanent, freely available resource for future scientific discovery while respecting access and benefit sharing guidelines of the Nagoya Protocol. We also describe scientific and organizational challenges in executing such an ambitious project, and the structure proposed to achieve the project's goals. The far-reaching potential benefits of creating an open digital repository of genomic information for life on Earth can be realized only by a coordinated international effort.

Duke Scholars

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Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

April 2018

Volume

115

Issue

17

Start / End Page

4325 / 4333

Related Subject Headings

  • High-Throughput Nucleotide Sequencing
  • Genome
  • Endangered Species
  • Earth, Planet
  • Biodiversity
 

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Lewin, H. A., Robinson, G. E., Kress, W. J., Baker, W. J., Coddington, J., Crandall, K. A., … Zhang, G. (2018). Earth BioGenome Project: Sequencing life for the future of life. Proceedings of the National Academy of Sciences of the United States of America, 115(17), 4325–4333. https://doi.org/10.1073/pnas.1720115115
Lewin, Harris A., Gene E. Robinson, W John Kress, William J. Baker, Jonathan Coddington, Keith A. Crandall, Richard Durbin, et al. “Earth BioGenome Project: Sequencing life for the future of life.Proceedings of the National Academy of Sciences of the United States of America 115, no. 17 (April 2018): 4325–33. https://doi.org/10.1073/pnas.1720115115.
Lewin HA, Robinson GE, Kress WJ, Baker WJ, Coddington J, Crandall KA, et al. Earth BioGenome Project: Sequencing life for the future of life. Proceedings of the National Academy of Sciences of the United States of America. 2018 Apr;115(17):4325–33.
Lewin, Harris A., et al. “Earth BioGenome Project: Sequencing life for the future of life.Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 17, Apr. 2018, pp. 4325–33. Epmc, doi:10.1073/pnas.1720115115.
Lewin HA, Robinson GE, Kress WJ, Baker WJ, Coddington J, Crandall KA, Durbin R, Edwards SV, Forest F, Gilbert MTP, Goldstein MM, Grigoriev IV, Hackett KJ, Haussler D, Jarvis ED, Johnson WE, Patrinos A, Richards S, Castilla-Rubio JC, van Sluys M-A, Soltis PS, Xu X, Yang H, Zhang G. Earth BioGenome Project: Sequencing life for the future of life. Proceedings of the National Academy of Sciences of the United States of America. 2018 Apr;115(17):4325–4333.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

April 2018

Volume

115

Issue

17

Start / End Page

4325 / 4333

Related Subject Headings

  • High-Throughput Nucleotide Sequencing
  • Genome
  • Endangered Species
  • Earth, Planet
  • Biodiversity