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Threatened miscarriage and depressive and anxiety symptoms among women and partners in early pregnancy.

Publication ,  Journal Article
Zhu, CS; Tan, TC; Chen, HY; Malhotra, R; Allen, JC; Østbye, T
Published in: J Affect Disord
September 2018

BACKGROUND: Antenatal depression has been associated with poor maternal and fetal outcomes, and threatened miscarriage is often seen clinically to impact adversely on maternal wellbeing, notwithstanding the limited research evidence. Our study aims to examine the link between threatened miscarriage and antenatal depression and anxiety in an Asian obstetric population. METHODS: We recruited 121 women and 68 partners facing threatened miscarriage, and 241 women and 180 partners experiencing uncomplicated pregnancies from a tertiary maternity hospital in Singapore. All participants completed a Patient Information Questionnaire and the Edinburgh Postnatal Depression Scale (EPDS). RESULTS: The proportion of women with major depressive and anxiety symptomatology was significantly higher among women facing threatened miscarriage compared to those with stable pregnancies (depressive: 33.1% vs. 17.0%, p = 0.008; anxiety: 48.8% vs. 23.7%, p < 0.0001). Amongst their partners, there was a non-significant trend towards a similar finding (depressive: 10.3% vs. 7.2%, p = 0.439; anxiety: 23.5% vs. 18.9%, p = 0.478). Threatened miscarriage remained significantly associated with major depressive symptomatology after adjusting for potential confounders among women (OR 2.70; 95% CI 1.55, 4.71; p < 0.0001) but not among their partners (OR 1.47; 95% CI 0.56, 3.87; p = 0.430). LIMITATIONS: This study is limited by its cross-sectional design and relatively small sample size for male partners. CONCLUSION: Antenatal depressive and anxiety symptomatology affects one in four women in their first trimester, with even higher prevalence among women facing threatened miscarriage. Targeted depression and anxiety screening that includes women facing threatened miscarriages may facilitate early and efficient detection and management of mental health problems among pregnant women.

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Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

September 2018

Volume

237

Start / End Page

1 / 9

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Surveys and Questionnaires
  • Singapore
  • Sexual Partners
  • Risk Factors
  • Psychiatry
  • Prevalence
  • Prenatal Care
  • Pregnant Women
  • Pregnancy Trimester, First
 

Citation

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ICMJE
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Zhu, C. S., Tan, T. C., Chen, H. Y., Malhotra, R., Allen, J. C., & Østbye, T. (2018). Threatened miscarriage and depressive and anxiety symptoms among women and partners in early pregnancy. J Affect Disord, 237, 1–9. https://doi.org/10.1016/j.jad.2018.04.012
Zhu, Cindy Shiqi, Thiam Chye Tan, Helen Yu Chen, Rahul Malhotra, John Carson Allen, and Truls Østbye. “Threatened miscarriage and depressive and anxiety symptoms among women and partners in early pregnancy.J Affect Disord 237 (September 2018): 1–9. https://doi.org/10.1016/j.jad.2018.04.012.
Zhu CS, Tan TC, Chen HY, Malhotra R, Allen JC, Østbye T. Threatened miscarriage and depressive and anxiety symptoms among women and partners in early pregnancy. J Affect Disord. 2018 Sep;237:1–9.
Zhu, Cindy Shiqi, et al. “Threatened miscarriage and depressive and anxiety symptoms among women and partners in early pregnancy.J Affect Disord, vol. 237, Sept. 2018, pp. 1–9. Pubmed, doi:10.1016/j.jad.2018.04.012.
Zhu CS, Tan TC, Chen HY, Malhotra R, Allen JC, Østbye T. Threatened miscarriage and depressive and anxiety symptoms among women and partners in early pregnancy. J Affect Disord. 2018 Sep;237:1–9.
Journal cover image

Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

September 2018

Volume

237

Start / End Page

1 / 9

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Surveys and Questionnaires
  • Singapore
  • Sexual Partners
  • Risk Factors
  • Psychiatry
  • Prevalence
  • Prenatal Care
  • Pregnant Women
  • Pregnancy Trimester, First