Skip to main content
Journal cover image

EuroPhenome: a repository for high-throughput mouse phenotyping data.

Publication ,  Journal Article
Morgan, H; Beck, T; Blake, A; Gates, H; Adams, N; Debouzy, G; Leblanc, S; Lengger, C; Maier, H; Melvin, D; Meziane, H; Richardson, D; Wood, J ...
Published in: Nucleic Acids Res
January 2010

The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information to allow deeper understanding of the processes leading from genomic changes to altered phenotype and disease. The EuroPhenome project (http://www.EuroPhenome.org) is a comprehensive resource for raw and annotated high-throughput phenotyping data arising from projects such as EUMODIC. EUMODIC is gathering data from the EMPReSSslim pipeline (http://www.empress.har.mrc.ac.uk/) which is performed on inbred mouse strains and knock-out lines arising from the EUCOMM project. The EuroPhenome interface allows the user to access the data via the phenotype or genotype. It also allows the user to access the data in a variety of ways, including graphical display, statistical analysis and access to the raw data via web services. The raw phenotyping data captured in EuroPhenome is annotated by an annotation pipeline which automatically identifies statistically different mutants from the appropriate baseline and assigns ontology terms for that specific test. Mutant phenotypes can be quickly identified using two EuroPhenome tools: PhenoMap, a graphical representation of statistically relevant phenotypes, and mining for a mutant using ontology terms. To assist with data definition and cross-database comparisons, phenotype data is annotated using combinations of terms from biological ontologies.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nucleic Acids Res

DOI

EISSN

1362-4962

Publication Date

January 2010

Volume

38

Issue

Database issue

Start / End Page

D577 / D585

Location

England

Related Subject Headings

  • Software
  • Protein Structure, Tertiary
  • Programming Languages
  • Phenotype
  • Mice, Knockout
  • Mice, Inbred Strains
  • Mice, Inbred C57BL
  • Mice
  • Internet
  • Information Storage and Retrieval
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Morgan, H., Beck, T., Blake, A., Gates, H., Adams, N., Debouzy, G., … Mallon, A.-M. (2010). EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res, 38(Database issue), D577–D585. https://doi.org/10.1093/nar/gkp1007
Morgan, Hugh, Tim Beck, Andrew Blake, Hilary Gates, Niels Adams, Guillaume Debouzy, Sophie Leblanc, et al. “EuroPhenome: a repository for high-throughput mouse phenotyping data.Nucleic Acids Res 38, no. Database issue (January 2010): D577–85. https://doi.org/10.1093/nar/gkp1007.
Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, et al. EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res. 2010 Jan;38(Database issue):D577–85.
Morgan, Hugh, et al. “EuroPhenome: a repository for high-throughput mouse phenotyping data.Nucleic Acids Res, vol. 38, no. Database issue, Jan. 2010, pp. D577–85. Pubmed, doi:10.1093/nar/gkp1007.
Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J, EUMODIC Consortium, de Angelis MH, Brown SDM, Hancock JM, Mallon A-M. EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res. 2010 Jan;38(Database issue):D577–D585.
Journal cover image

Published In

Nucleic Acids Res

DOI

EISSN

1362-4962

Publication Date

January 2010

Volume

38

Issue

Database issue

Start / End Page

D577 / D585

Location

England

Related Subject Headings

  • Software
  • Protein Structure, Tertiary
  • Programming Languages
  • Phenotype
  • Mice, Knockout
  • Mice, Inbred Strains
  • Mice, Inbred C57BL
  • Mice
  • Internet
  • Information Storage and Retrieval