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Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke.

Publication ,  Journal Article
Nih, LR; Gojgini, S; Carmichael, ST; Segura, T
Published in: Nature materials
July 2018

Stroke is the primary cause of disability due to the brain's limited ability to regenerate damaged tissue. After stroke, an increased inflammatory and immune response coupled with severely limited angiogenesis and neuronal growth results in a stroke cavity devoid of normal brain tissue. In the adult, therapeutic angiogenic materials have been used to repair ischaemic tissues through the formation of vascular networks. However, whether a therapeutic angiogenic material can regenerate brain tissue and promote neural repair is poorly understood. Here we show that the delivery of an engineered immune-modulating angiogenic biomaterial directly to the stroke cavity promotes tissue formation de novo, and results in axonal networks along thee generated blood vessels. This regenerated tissue produces functional recovery through the established axonal networks. Thus, this biomaterials approach generates a vascularized network of regenerated functional neuronal connections within previously dead tissue and lays the groundwork for the use of angiogenic materials to repair other neurologically diseased tissues.

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Published In

Nature materials

DOI

EISSN

1476-4660

ISSN

1476-1122

Publication Date

July 2018

Volume

17

Issue

7

Start / End Page

642 / 651

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Stroke
  • Recovery of Function
  • Neurogenesis
  • Neovascularization, Physiologic
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Humans
  • Heparin
  • Brain
 

Citation

APA
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Nih, L. R., Gojgini, S., Carmichael, S. T., & Segura, T. (2018). Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. Nature Materials, 17(7), 642–651. https://doi.org/10.1038/s41563-018-0083-8
Nih, Lina R., Shiva Gojgini, S Thomas Carmichael, and Tatiana Segura. “Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke.Nature Materials 17, no. 7 (July 2018): 642–51. https://doi.org/10.1038/s41563-018-0083-8.
Nih LR, Gojgini S, Carmichael ST, Segura T. Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. Nature materials. 2018 Jul;17(7):642–51.
Nih, Lina R., et al. “Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke.Nature Materials, vol. 17, no. 7, July 2018, pp. 642–51. Epmc, doi:10.1038/s41563-018-0083-8.
Nih LR, Gojgini S, Carmichael ST, Segura T. Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. Nature materials. 2018 Jul;17(7):642–651.

Published In

Nature materials

DOI

EISSN

1476-4660

ISSN

1476-1122

Publication Date

July 2018

Volume

17

Issue

7

Start / End Page

642 / 651

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Stroke
  • Recovery of Function
  • Neurogenesis
  • Neovascularization, Physiologic
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Humans
  • Heparin
  • Brain