Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Synthetic transcription factors for cell fate reprogramming.

Publication ,  Journal Article
Black, JB; Gersbach, CA
Published in: Current opinion in genetics & development
October 2018

The ability to reprogram cell lineage specification through the activity of master regulatory transcription factors has transformed disease modeling, drug screening, and cell therapy for regenerative medicine. Recent advances in the engineering of synthetic transcription factors to modulate endogenous gene expression networks and chromatin states have generated a new set of tools with unique advantages to study and enhance cell reprogramming methods. Several studies have applied synthetic transcription factors in various cell reprogramming paradigms in human and murine cells. Moreover, the adaption of CRISPR-based transcription factors for high-throughput screening will enable the systematic identification of optimal factors and gene network perturbations to improve current reprogramming protocols and enable conversion to more diverse, highly specified, and mature cell types. The rapid development of next-generation technologies with more robust and versatile functionality will continue to expand the application of synthetic transcription factors for cell reprogramming.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Current opinion in genetics & development

DOI

EISSN

1879-0380

ISSN

0959-437X

Publication Date

October 2018

Volume

52

Start / End Page

13 / 21

Related Subject Headings

  • Regenerative Medicine
  • Mice
  • Induced Pluripotent Stem Cells
  • Humans
  • Developmental Biology
  • Chromatin
  • Cellular Reprogramming
  • Cell Lineage
  • Cell Differentiation
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Black, J. B., & Gersbach, C. A. (2018). Synthetic transcription factors for cell fate reprogramming. Current Opinion in Genetics & Development, 52, 13–21. https://doi.org/10.1016/j.gde.2018.05.001
Black, Joshua B., and Charles A. Gersbach. “Synthetic transcription factors for cell fate reprogramming.Current Opinion in Genetics & Development 52 (October 2018): 13–21. https://doi.org/10.1016/j.gde.2018.05.001.
Black JB, Gersbach CA. Synthetic transcription factors for cell fate reprogramming. Current opinion in genetics & development. 2018 Oct;52:13–21.
Black, Joshua B., and Charles A. Gersbach. “Synthetic transcription factors for cell fate reprogramming.Current Opinion in Genetics & Development, vol. 52, Oct. 2018, pp. 13–21. Epmc, doi:10.1016/j.gde.2018.05.001.
Black JB, Gersbach CA. Synthetic transcription factors for cell fate reprogramming. Current opinion in genetics & development. 2018 Oct;52:13–21.
Journal cover image

Published In

Current opinion in genetics & development

DOI

EISSN

1879-0380

ISSN

0959-437X

Publication Date

October 2018

Volume

52

Start / End Page

13 / 21

Related Subject Headings

  • Regenerative Medicine
  • Mice
  • Induced Pluripotent Stem Cells
  • Humans
  • Developmental Biology
  • Chromatin
  • Cellular Reprogramming
  • Cell Lineage
  • Cell Differentiation
  • Animals