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Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs.

Publication ,  Journal Article
Zhu, S; Li, S; Escuin-Ordinas, H; Dimatteo, R; Xi, W; Ribas, A; Segura, T
Published in: Journal of controlled release : official journal of the Controlled Release Society
July 2018

Injectable hydrogel matrices take the shape of a wound cavity and serve as scaffold for tissue repair and regeneration. Yet these materials are generally hydrophilic, limiting the incorporation of poorly water soluble, hydrophobic drugs. Here we show this shortcoming is circumvented through a star-shaped amphiphilic block copolymer comprising poly(ethylene glycol) and poly (propylene sulfide). This star-shaped amphiphilic polymer self-assembles in an aqueous medium into a physically stable hydrogel and effectively dissolves hydrophobic molecules delivering them at therapeutic doses. The self assembled hydrogel is a robust three-dimensional scaffold in vivo effectively promoting cellular infiltration, reducing inflammation, and wound clsoure. When combined with a hydrophobic BRAF inhibitor that promotes paradoxical mitogen-activated protein kinase (MAPK) activation in keratinocytes and wound closure, our self assembled scaffold supported dermal wound closure at a reduced drug dosage compared to administering the drug in dimethyl sulfoxide (DMSO) without a polymeric matrix. This family of star-shaped amphiphilic polymers delivers poorly water soluble active agents at a fraction of generally required dosage for efficacy and supports three-dimensional cell growth at tissue wounds, showing great promise for novel uses of hydrophobic drugs in tissue repair applications.

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Published In

Journal of controlled release : official journal of the Controlled Release Society

DOI

EISSN

1873-4995

ISSN

0168-3659

Publication Date

July 2018

Volume

282

Start / End Page

156 / 165

Related Subject Headings

  • Wound Healing
  • Water
  • Vemurafenib
  • Sulfides
  • Solubility
  • Protein Kinase Inhibitors
  • Polymers
  • Polyethylene Glycols
  • Pharmacology & Pharmacy
  • Mice
 

Citation

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MLA
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Zhu, S., Li, S., Escuin-Ordinas, H., Dimatteo, R., Xi, W., Ribas, A., & Segura, T. (2018). Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs. Journal of Controlled Release : Official Journal of the Controlled Release Society, 282, 156–165. https://doi.org/10.1016/j.jconrel.2018.05.006
Zhu, Suwei, Shuoran Li, Helena Escuin-Ordinas, Robert Dimatteo, Weixian Xi, Antoni Ribas, and Tatiana Segura. “Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs.Journal of Controlled Release : Official Journal of the Controlled Release Society 282 (July 2018): 156–65. https://doi.org/10.1016/j.jconrel.2018.05.006.
Zhu S, Li S, Escuin-Ordinas H, Dimatteo R, Xi W, Ribas A, et al. Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs. Journal of controlled release : official journal of the Controlled Release Society. 2018 Jul;282:156–65.
Zhu, Suwei, et al. “Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs.Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 282, July 2018, pp. 156–65. Epmc, doi:10.1016/j.jconrel.2018.05.006.
Zhu S, Li S, Escuin-Ordinas H, Dimatteo R, Xi W, Ribas A, Segura T. Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs. Journal of controlled release : official journal of the Controlled Release Society. 2018 Jul;282:156–165.
Journal cover image

Published In

Journal of controlled release : official journal of the Controlled Release Society

DOI

EISSN

1873-4995

ISSN

0168-3659

Publication Date

July 2018

Volume

282

Start / End Page

156 / 165

Related Subject Headings

  • Wound Healing
  • Water
  • Vemurafenib
  • Sulfides
  • Solubility
  • Protein Kinase Inhibitors
  • Polymers
  • Polyethylene Glycols
  • Pharmacology & Pharmacy
  • Mice