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Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study.

Publication ,  Journal Article
Odden, MC; Wu, C; Shlipak, MG; Psaty, BM; Katz, R; Applegate, WB; Harris, T; Newman, AB; Peralta, CA; Health ABC Study,
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
December 2016

The present study aimed to (i) evaluate previous observations that the association of blood pressure (BP) with outcomes varies by gait speed and (ii) evaluate the association of subsequent changes in BP and cardiovascular risk.Participants included 2,669 adults aged 70-79 years in the Health, Aging, and Body Composition (Health ABC) study. Gait speed was dichotomized at ≥1.0 m/s over a 20-m test at baseline. BP was measured at baseline, and changes in BP over 5 years were evaluated using (i) population-based trajectory models and (ii) intraindividual mean and slope.Over a mean of 10 years, there were 1,366 deaths, 336 first myocardial infarctions, and 295 first strokes. There was a differential pattern of association between baseline systolic BP and diastolic BP and outcomes among brisk and moderate speed walkers. For example, the association between higher diastolic BP and mortality was in the protective direction for moderate speed walkers (hazard ratio = 0.75; 95% confidence interval: 0.63, 0.91) per 10 mmHg higher, whereas it was null in brisk walkers (hazard ratio = 1.05; 95% confidence interval: 0.98, 1.11), p value for interaction .01. The 5-year population-based trajectories did not add important information beyond baseline BP. Individual slopes in both systolic BP and diastolic BP did not appear to have important associations with the outcomes.In this study, we found that the overall level of BP was associated with myocardial infarction, stroke, and death, and this association differed by baseline gait speed, whereas changes in BP were not associated with these outcomes.

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Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

December 2016

Volume

71

Issue

12

Start / End Page

1688 / 1694

Related Subject Headings

  • Walking Speed
  • Tennessee
  • Risk Assessment
  • Prospective Studies
  • Pennsylvania
  • Male
  • Incidence
  • Humans
  • Gerontology
  • Geriatric Assessment
 

Citation

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Odden, M. C., Wu, C., Shlipak, M. G., Psaty, B. M., Katz, R., Applegate, W. B., … Health ABC Study, . (2016). Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 71(12), 1688–1694. https://doi.org/10.1093/gerona/glw076
Odden, Michelle C., Chenkai Wu, Michael G. Shlipak, Bruce M. Psaty, Ronit Katz, William B. Applegate, Tamara Harris, Anne B. Newman, Carmen A. Peralta, and Carmen A. Health ABC Study. “Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 71, no. 12 (December 2016): 1688–94. https://doi.org/10.1093/gerona/glw076.
Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, et al. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2016 Dec;71(12):1688–94.
Odden, Michelle C., et al. “Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 71, no. 12, Dec. 2016, pp. 1688–94. Epmc, doi:10.1093/gerona/glw076.
Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA, Health ABC Study. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2016 Dec;71(12):1688–1694.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

December 2016

Volume

71

Issue

12

Start / End Page

1688 / 1694

Related Subject Headings

  • Walking Speed
  • Tennessee
  • Risk Assessment
  • Prospective Studies
  • Pennsylvania
  • Male
  • Incidence
  • Humans
  • Gerontology
  • Geriatric Assessment