Measurements of humoral immune responses directed to HIV-1: Comparison of infection and vaccine induced antibody reactivities
Neutralizing antibody repsonses to natural infection of humans and experimental infection of chimpanzees are compared to those induced by candidate HIV-1 vaccines and to several monoclonal antibodies. The studies were directed to the apparent neutralization resistance of primary HIV-1 isolates. The results suggest that in one chimpanzee model of a 'primary' virus infection the polyclonal neutralizing responses were especialy potent, although extremely restricted in breadth of neutralization of divergent isolates. Neutralization of primary isolates by HIV+ sera or vaccinee sera was rare. Several human monoclonal antibodies however were active against primary isolates although the potency of these was several orders of magnitude lower than observed for laboratory adapted HIV-1 isolates.
