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Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).

Publication ,  Journal Article
Lam, M; Trampush, JW; Yu, J; Knowles, E; Djurovic, S; Melle, I; Sundet, K; Christoforou, A; Reinvang, I; DeRosse, P; Lundervold, AJ; Steen, VM ...
Published in: Twin Res Hum Genet
October 2018

Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84-88) presented a critique of our recently published paper in Cell Reports entitled 'Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets' (Lam et al., Cell Reports, Vol. 21, 2017, 2597-2613). Specifically, Hill offered several interrelated comments suggesting potential problems with our use of a new analytic method called Multi-Trait Analysis of GWAS (MTAG) (Turley et al., Nature Genetics, Vol. 50, 2018, 229-237). In this brief article, we respond to each of these concerns. Using empirical data, we conclude that our MTAG results do not suffer from 'inflation in the FDR [false discovery rate]', as suggested by Hill (Twin Research and Human Genetics, Vol. 21, 2018, 84-88), and are not 'more relevant to the genetic contributions to education than they are to the genetic contributions to intelligence'.

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Published In

Twin Res Hum Genet

DOI

ISSN

1832-4274

Publication Date

October 2018

Volume

21

Issue

5

Start / End Page

394 / 397

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Nootropic Agents
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Cognition
  • 3215 Reproductive medicine
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences
 

Citation

APA
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Lam, M., Trampush, J. W., Yu, J., Knowles, E., Djurovic, S., Melle, I., … Lencz, T. (2018). Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018). Twin Res Hum Genet, 21(5), 394–397. https://doi.org/10.1017/thg.2018.46
Lam, Max, Joey W. Trampush, Jin Yu, Emma Knowles, Srdjan Djurovic, Ingrid Melle, Kjetil Sundet, et al. “Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).Twin Res Hum Genet 21, no. 5 (October 2018): 394–97. https://doi.org/10.1017/thg.2018.46.
Lam M, Trampush JW, Yu J, Knowles E, Djurovic S, Melle I, et al. Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018). Twin Res Hum Genet. 2018 Oct;21(5):394–7.
Lam, Max, et al. “Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018).Twin Res Hum Genet, vol. 21, no. 5, Oct. 2018, pp. 394–97. Pubmed, doi:10.1017/thg.2018.46.
Lam M, Trampush JW, Yu J, Knowles E, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Hellard SL, Keller MC, Andreassen OA, Glahn DC, Malhotra AK, Lencz T. Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018). Twin Res Hum Genet. 2018 Oct;21(5):394–397.
Journal cover image

Published In

Twin Res Hum Genet

DOI

ISSN

1832-4274

Publication Date

October 2018

Volume

21

Issue

5

Start / End Page

394 / 397

Location

England

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Nootropic Agents
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Cognition
  • 3215 Reproductive medicine
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences