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Perianesthetic Implications and Considerations for Myasthenia Gravis.

Publication ,  Journal Article
Muckler, VC; O'Brien, JM; Matson, SE; Rice, AN
Published in: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses
February 2019

Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease in which antibodies against the post-nicotinic acetylcholine receptor at the neuromuscular junction develop. Although the exact cause of MG remains unknown, the thymus is a common factor in many cases. Patients with underlying junctional disease, such as MG, have greater anesthesia-related risks because of their known predisposition toward prolonged muscle weakness. Medications given in the perioperative period, such as anesthetic agents, antibiotics, cardiovascular drugs, and corticosteroids, affect neuromuscular transmission that contributes to muscle weakness. Judicious use of neuromuscular blocking agents for patients with MG must be considered. This patient population is at high risk for respiratory failure, and therefore must be carefully assessed throughout the perioperative period to ensure that a regular spontaneous respiratory pattern is sufficient to provide adequate oxygenation. Perianesthesia providers must consider anesthetic, ventilatory, and pharmacologic implications when proposing, providing, and recovering anesthesia for the patient with MG.

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Published In

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

DOI

EISSN

1532-8473

ISSN

1089-9472

Publication Date

February 2019

Volume

34

Issue

1

Start / End Page

4 / 15

Related Subject Headings

  • Preoperative Care
  • Nursing
  • Neuromuscular Blocking Agents
  • Myasthenia Gravis
  • Humans
  • Anesthetics
  • Anesthesia
  • 4205 Nursing
  • 4204 Midwifery
  • 1110 Nursing
 

Citation

APA
Chicago
ICMJE
MLA
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Muckler, V. C., O’Brien, J. M., Matson, S. E., & Rice, A. N. (2019). Perianesthetic Implications and Considerations for Myasthenia Gravis. Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses, 34(1), 4–15. https://doi.org/10.1016/j.jopan.2018.03.009
Muckler, Virginia C., Jennifer M. O’Brien, Stephen E. Matson, and Andi N. Rice. “Perianesthetic Implications and Considerations for Myasthenia Gravis.Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses 34, no. 1 (February 2019): 4–15. https://doi.org/10.1016/j.jopan.2018.03.009.
Muckler VC, O’Brien JM, Matson SE, Rice AN. Perianesthetic Implications and Considerations for Myasthenia Gravis. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses. 2019 Feb;34(1):4–15.
Muckler, Virginia C., et al. “Perianesthetic Implications and Considerations for Myasthenia Gravis.Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses, vol. 34, no. 1, Feb. 2019, pp. 4–15. Epmc, doi:10.1016/j.jopan.2018.03.009.
Muckler VC, O’Brien JM, Matson SE, Rice AN. Perianesthetic Implications and Considerations for Myasthenia Gravis. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses. 2019 Feb;34(1):4–15.
Journal cover image

Published In

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

DOI

EISSN

1532-8473

ISSN

1089-9472

Publication Date

February 2019

Volume

34

Issue

1

Start / End Page

4 / 15

Related Subject Headings

  • Preoperative Care
  • Nursing
  • Neuromuscular Blocking Agents
  • Myasthenia Gravis
  • Humans
  • Anesthetics
  • Anesthesia
  • 4205 Nursing
  • 4204 Midwifery
  • 1110 Nursing