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Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.

Publication ,  Journal Article
Reyes, NJ; Yu, C; Mathew, R; Kunnen, CM; Kalnitsky, J; Redfern, RL; Leonardi, A; Perez, VL; MacLeod, AS; Gupta, PK; Saban, DR
Published in: Sci Transl Med
July 25, 2018

Meibomian glands (MGs) are sebaceous glands of the eyelid margin that secrete lipids needed to avert tear evaporation and to help maintain ocular surface homeostasis. Obstruction of MGs or other forms of MG dysfunction can promote chronic diseases of the ocular surface. Although chronic eyelid inflammation, such as allergic eye disease, is an associated risk factor for obstructive MG dysfunction, it is not clear whether inflammatory processes contribute to the pathophysiology of MG obstruction. We show that polymorphonuclear neutrophils (PMNs) promoted MG obstruction in a chronic inflammatory model of allergic eye disease in mice. Analysis of leukocytes in tears of patients with MG dysfunction showed an increase in PMN numbers compared to healthy subjects. Moreover, PMN numbers in tears positively correlated with clinical severity of MG dysfunction. Our findings point to a role for PMNs in the pathogenesis and progression of MG dysfunction.

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Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

July 25, 2018

Volume

10

Issue

451

Location

United States

Related Subject Headings

  • Sebaceous Glands
  • Neutrophils
  • Mice, Inbred C57BL
  • Mice
  • Meibomian Glands
  • Eyelid Diseases
  • Animals
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 11 Medical and Health Sciences
 

Citation

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Reyes, N. J., Yu, C., Mathew, R., Kunnen, C. M., Kalnitsky, J., Redfern, R. L., … Saban, D. R. (2018). Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice. Sci Transl Med, 10(451). https://doi.org/10.1126/scitranslmed.aas9164
Reyes, Nancy J., Chen Yu, Rose Mathew, Carolina M. Kunnen, Joan Kalnitsky, Rachel L. Redfern, Andrea Leonardi, et al. “Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.Sci Transl Med 10, no. 451 (July 25, 2018). https://doi.org/10.1126/scitranslmed.aas9164.
Reyes NJ, Yu C, Mathew R, Kunnen CM, Kalnitsky J, Redfern RL, et al. Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice. Sci Transl Med. 2018 Jul 25;10(451).
Reyes, Nancy J., et al. “Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.Sci Transl Med, vol. 10, no. 451, July 2018. Pubmed, doi:10.1126/scitranslmed.aas9164.
Reyes NJ, Yu C, Mathew R, Kunnen CM, Kalnitsky J, Redfern RL, Leonardi A, Perez VL, MacLeod AS, Gupta PK, Saban DR. Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice. Sci Transl Med. 2018 Jul 25;10(451).

Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

July 25, 2018

Volume

10

Issue

451

Location

United States

Related Subject Headings

  • Sebaceous Glands
  • Neutrophils
  • Mice, Inbred C57BL
  • Mice
  • Meibomian Glands
  • Eyelid Diseases
  • Animals
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
  • 11 Medical and Health Sciences