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Transcriptional signature primes human oral mucosa for rapid wound healing.

Publication ,  Journal Article
Iglesias-Bartolome, R; Uchiyama, A; Molinolo, AA; Abusleme, L; Brooks, SR; Callejas-Valera, JL; Edwards, D; Doci, C; Asselin-Labat, M-L ...
Published in: Sci Transl Med
July 25, 2018

Oral mucosal wound healing has long been regarded as an ideal system of wound resolution. However, the intrinsic characteristics that mediate optimal healing at mucosal surfaces are poorly understood, particularly in humans. We present a unique comparative analysis between human oral and cutaneous wound healing using paired and sequential biopsies during the repair process. Using molecular profiling, we determined that wound-activated transcriptional networks are present at basal state in the oral mucosa, priming the epithelium for wound repair. We show that oral mucosal wound-related networks control epithelial cell differentiation and regulate inflammatory responses, highlighting fundamental global mechanisms of repair and inflammatory responses in humans. The paired comparative analysis allowed for the identification of differentially expressed SOX2 (sex-determining region Y-box 2) and PITX1 (paired-like homeodomain 1) transcriptional regulators in oral versus skin keratinocytes, conferring a unique identity to oral keratinocytes. We show that SOX2 and PITX1 transcriptional function has the potential to reprogram skin keratinocytes to increase cell migration and improve wound resolution in vivo. Our data provide insights into therapeutic targeting of chronic and nonhealing wounds based on greater understanding of the biology of healing in human mucosal and cutaneous environments.

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Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

July 25, 2018

Volume

10

Issue

451

Location

United States

Related Subject Headings

  • Wound Healing
  • Transcription Factors
  • Skin
  • Mouth Mucosa
  • Keratinocytes
  • Humans
  • Biopsy
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Iglesias-Bartolome, R., Uchiyama, A., Molinolo, A. A., Abusleme, L., Brooks, S. R., Callejas-Valera, J. L., … Morasso, M. I. (2018). Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med, 10(451). https://doi.org/10.1126/scitranslmed.aap8798
Iglesias-Bartolome, Ramiro, Akihiko Uchiyama, Alfredo A. Molinolo, Loreto Abusleme, Stephen R. Brooks, Juan Luis Callejas-Valera, Dean Edwards, et al. “Transcriptional signature primes human oral mucosa for rapid wound healing.Sci Transl Med 10, no. 451 (July 25, 2018). https://doi.org/10.1126/scitranslmed.aap8798.
Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, et al. Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med. 2018 Jul 25;10(451).
Iglesias-Bartolome, Ramiro, et al. “Transcriptional signature primes human oral mucosa for rapid wound healing.Sci Transl Med, vol. 10, no. 451, July 2018. Pubmed, doi:10.1126/scitranslmed.aap8798.
Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat M-L, Onaitis MW, Moutsopoulos NM, Gutkind JS, Morasso MI. Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med. 2018 Jul 25;10(451).

Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

July 25, 2018

Volume

10

Issue

451

Location

United States

Related Subject Headings

  • Wound Healing
  • Transcription Factors
  • Skin
  • Mouth Mucosa
  • Keratinocytes
  • Humans
  • Biopsy
  • 11 Medical and Health Sciences
  • 06 Biological Sciences