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SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.

Publication ,  Journal Article
Diao, Y; Wang, X; Wu, Z
Published in: Mol Cell Biol
September 2009

We recently showed that a leukemia inhibitory factor (LIF)-engaged signaling pathway consisting of JAK1, STAT1, and STAT3 plays dual roles in myogenic differentiation: while it participates in myoblast proliferation, it also actively represses differentiation. Downregulation of this pathway is required at the onset of differentiation. However, it remained unclear how this is achieved mechanistically. We now show that SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by specifically inhibiting the LIF-induced JAK1/STAT1/STAT3 pathway via distinct targets; whereas SOCS1 and SOCS3 selectively bind and inhibit JAK1 and gp130, respectively, PIAS1 targets mainly the activated STAT1 and prevents its binding to DNA. We further demonstrated that the SUMO E3-ligase activity of PIAS1 is dispensable for its role in myogenic differentiation. Collectively, our current study revealed a molecular mechanism that explains how the LIF-induced JAK1/STAT1/STAT3 pathway is downregulated upon myogenic differentiation.

Duke Scholars

Published In

Mol Cell Biol

DOI

EISSN

1098-5549

Publication Date

September 2009

Volume

29

Issue

18

Start / End Page

5084 / 5093

Location

United States

Related Subject Headings

  • Transcription Factors
  • Suppressor of Cytokine Signaling Proteins
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling 1 Protein
  • Signal Transduction
  • STAT3 Transcription Factor
  • STAT1 Transcription Factor
  • Protein Inhibitors of Activated STAT
  • Myoblasts
  • Muscle Development
 

Citation

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Diao, Y., Wang, X., & Wu, Z. (2009). SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway. Mol Cell Biol, 29(18), 5084–5093. https://doi.org/10.1128/MCB.00267-09
Diao, Yarui, Xi Wang, and Zhenguo Wu. “SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.Mol Cell Biol 29, no. 18 (September 2009): 5084–93. https://doi.org/10.1128/MCB.00267-09.
Diao, Yarui, et al. “SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.Mol Cell Biol, vol. 29, no. 18, Sept. 2009, pp. 5084–93. Pubmed, doi:10.1128/MCB.00267-09.

Published In

Mol Cell Biol

DOI

EISSN

1098-5549

Publication Date

September 2009

Volume

29

Issue

18

Start / End Page

5084 / 5093

Location

United States

Related Subject Headings

  • Transcription Factors
  • Suppressor of Cytokine Signaling Proteins
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling 1 Protein
  • Signal Transduction
  • STAT3 Transcription Factor
  • STAT1 Transcription Factor
  • Protein Inhibitors of Activated STAT
  • Myoblasts
  • Muscle Development