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Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients.

Publication ,  Journal Article
Restrepo, MI; Babu, BL; Reyes, LF; Chalmers, JD; Soni, NJ; Sibila, O; Faverio, P; Cilloniz, C; Rodriguez-Cintron, W; Aliberti, S; GLIMP
Published in: Eur Respir J
August 2018

Pseudomonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP.We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP.The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases.The multinational prevalence of P. aeruginosa-CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients.

Duke Scholars

Published In

Eur Respir J

DOI

EISSN

1399-3003

Publication Date

August 2018

Volume

52

Issue

2

Location

England

Related Subject Headings

  • Tracheostomy
  • Risk Factors
  • Respiratory System
  • Pulmonary Disease, Chronic Obstructive
  • Pseudomonas aeruginosa
  • Prevalence
  • Pneumonia, Bacterial
  • Middle Aged
  • Male
  • Logistic Models
 

Citation

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Restrepo, M. I., Babu, B. L., Reyes, L. F., Chalmers, J. D., Soni, N. J., Sibila, O., … GLIMP. (2018). Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia: a multinational point prevalence study of hospitalised patients. Eur Respir J, 52(2). https://doi.org/10.1183/13993003.01190-2017
Journal cover image

Published In

Eur Respir J

DOI

EISSN

1399-3003

Publication Date

August 2018

Volume

52

Issue

2

Location

England

Related Subject Headings

  • Tracheostomy
  • Risk Factors
  • Respiratory System
  • Pulmonary Disease, Chronic Obstructive
  • Pseudomonas aeruginosa
  • Prevalence
  • Pneumonia, Bacterial
  • Middle Aged
  • Male
  • Logistic Models