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Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.

Publication ,  Journal Article
Deng, G-M; Zheng, L; Chan, FK-M; Lenardo, M
Published in: Nat Med
October 2005
Published version (DOI) Link to item

Tumor necrosis factor (TNF)-alpha has an important role in the pathogenesis of autoimmune and inflammatory diseases such as rheumatoid and septic arthritis. The biological effects of TNF-alpha are mediated by binding to TNF receptors TNFR1 (also known as P60) or TNFR2 (also known as P80). The pre-ligand assembly domain (PLAD) is a portion of the extracellular region of TNFRs that mediates receptor-chain association essential for signaling. We found that soluble versions of PLAD, especially those derived from P60, block the biochemical effects of TNF-alpha in vitro and potently inhibit arthritis in animal models. Thus, targeting the PLAD may have clinical value in the treatment of human arthritis and other disorders involving receptors of the TNFR superfamily.

Duke Scholars

Francis Ka-Ming Chan
Author Francis Ka-Ming Chan Integrative Immunobiology
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Published In

Nat Med

DOI

10.1038/nm1304

ISSN

1078-8956

Publication Date

October 2005

Volume

11

Issue

10

Start / End Page

1066 / 1072

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Recombinant Fusion Proteins
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • Protein Structure, Tertiary
  • Mice, Transgenic
  • Mice, Knockout
  • Mice
  • Ligands
 

Citation

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Deng, G.-M., Zheng, L., Chan, F.-M., & Lenardo, M. (2005). Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. Nat Med, 11(10), 1066–1072. https://doi.org/10.1038/nm1304
Deng, Guo-Min, Lixin Zheng, Francis Ka-Ming Chan, and Michael Lenardo. “Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.” Nat Med 11, no. 10 (October 2005): 1066–72. https://doi.org/10.1038/nm1304.
Deng, Guo-Min, et al. “Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.” Nat Med, vol. 11, no. 10, Oct. 2005, pp. 1066–72. Pubmed, doi:10.1038/nm1304.
Deng G-M, Zheng L, Chan FK-M, Lenardo M. Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. Nat Med. 2005 Oct;11(10):1066–1072.

Published In

Nat Med

DOI

10.1038/nm1304

ISSN

1078-8956

Publication Date

October 2005

Volume

11

Issue

10

Start / End Page

1066 / 1072

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Recombinant Fusion Proteins
  • Receptors, Tumor Necrosis Factor, Type II
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • Protein Structure, Tertiary
  • Mice, Transgenic
  • Mice, Knockout
  • Mice
  • Ligands