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Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.

Publication ,  Journal Article
Ong, J-S; Hwang, L-D; Cuellar-Partida, G; Martin, NG; Chenevix-Trench, G; Quinn, MCJ; Cornelis, MC; Gharahkhani, P; Webb, PM; MacGregor, S ...
Published in: Int J Epidemiol
April 1, 2018

BACKGROUND: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. METHODS: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator. RESULTS: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80 mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases. CONCLUSIONS: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

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Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

April 1, 2018

Volume

47

Issue

2

Start / End Page

450 / 459

Location

England

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Odds Ratio
  • Mendelian Randomization Analysis
  • Humans
  • Female
  • Epidemiology
  • Coffee
  • Carcinoma, Ovarian Epithelial
 

Citation

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Ong, J.-S., Hwang, L.-D., Cuellar-Partida, G., Martin, N. G., Chenevix-Trench, G., Quinn, M. C. J., … Ovarian Cancer Association Consortium, . (2018). Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. Int J Epidemiol, 47(2), 450–459. https://doi.org/10.1093/ije/dyx236
Ong, Jue-Sheng, Liang-Dar Hwang, Gabriel Cuellar-Partida, Nicholas G. Martin, Georgia Chenevix-Trench, Michael C. J. Quinn, Marilyn C. Cornelis, et al. “Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.Int J Epidemiol 47, no. 2 (April 1, 2018): 450–59. https://doi.org/10.1093/ije/dyx236.
Ong J-S, Hwang L-D, Cuellar-Partida G, Martin NG, Chenevix-Trench G, Quinn MCJ, et al. Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. Int J Epidemiol. 2018 Apr 1;47(2):450–9.
Ong, Jue-Sheng, et al. “Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study.Int J Epidemiol, vol. 47, no. 2, Apr. 2018, pp. 450–59. Pubmed, doi:10.1093/ije/dyx236.
Ong J-S, Hwang L-D, Cuellar-Partida G, Martin NG, Chenevix-Trench G, Quinn MCJ, Cornelis MC, Gharahkhani P, Webb PM, MacGregor S, Ovarian Cancer Association Consortium. Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. Int J Epidemiol. 2018 Apr 1;47(2):450–459.
Journal cover image

Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

April 1, 2018

Volume

47

Issue

2

Start / End Page

450 / 459

Location

England

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ovarian Neoplasms
  • Odds Ratio
  • Mendelian Randomization Analysis
  • Humans
  • Female
  • Epidemiology
  • Coffee
  • Carcinoma, Ovarian Epithelial