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The association of lumbar spondylolisthesis with collagen IX tryptophan alleles.

Publication ,  Journal Article
Matsui, Y; Mirza, SK; Wu, JJ; Carter, B; Bellabarba, C; Shaffrey, CI; Chapman, JR; Eyre, DR
Published in: J Bone Joint Surg Br
September 2004

Two collagen type IX gene polymorphisms that introduce a tryptophan residue into the protein's triple-helical domain have been linked to an increased risk of lumbar disc disease. To determine whether a particular subset of symptomatic lumbar disease is specifically associated with these polymorphisms, we performed a prospective case-control study of 107 patients who underwent surgery of the lumbar spine. Patients were assigned to one of five clinical categories (fracture, disc degeneration, disc herniation, spinal stenosis without spondylolisthesis and spinal stenosis with spondylolisthesis) based on history, imaging results, and findings during surgery. Of the 11 tryptophan-positive patients, eight had spinal stenosis with spondylolisthesis and three had disc herniation. The presence of the tryptophan allele was significantly associated with African-American or Asian designation for race (odds ratio 4.61, 95% CI 0.63 to 25.35) and with the diagnosis of spinal stenosis with spondylolisthesis (odds ratio 6.81, 95% CI 1.47 to 41.95). Our findings indicate that tryptophan polymorphisms predispose carriers to the development of symptomatic spinal stenosis associated with spondylolisthesis which requires surgery.

Duke Scholars

Published In

J Bone Joint Surg Br

DOI

ISSN

0301-620X

Publication Date

September 2004

Volume

86

Issue

7

Start / End Page

1021 / 1026

Location

England

Related Subject Headings

  • Tryptophan
  • Spondylolisthesis
  • Spinal Stenosis
  • Risk Factors
  • Radiography
  • Polymorphism, Genetic
  • Orthopedics
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
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Matsui, Y., Mirza, S. K., Wu, J. J., Carter, B., Bellabarba, C., Shaffrey, C. I., … Eyre, D. R. (2004). The association of lumbar spondylolisthesis with collagen IX tryptophan alleles. J Bone Joint Surg Br, 86(7), 1021–1026. https://doi.org/10.1302/0301-620x.86b7.14994
Matsui, Y., S. K. Mirza, J. J. Wu, B. Carter, C. Bellabarba, C. I. Shaffrey, J. R. Chapman, and D. R. Eyre. “The association of lumbar spondylolisthesis with collagen IX tryptophan alleles.J Bone Joint Surg Br 86, no. 7 (September 2004): 1021–26. https://doi.org/10.1302/0301-620x.86b7.14994.
Matsui Y, Mirza SK, Wu JJ, Carter B, Bellabarba C, Shaffrey CI, et al. The association of lumbar spondylolisthesis with collagen IX tryptophan alleles. J Bone Joint Surg Br. 2004 Sep;86(7):1021–6.
Matsui, Y., et al. “The association of lumbar spondylolisthesis with collagen IX tryptophan alleles.J Bone Joint Surg Br, vol. 86, no. 7, Sept. 2004, pp. 1021–26. Pubmed, doi:10.1302/0301-620x.86b7.14994.
Matsui Y, Mirza SK, Wu JJ, Carter B, Bellabarba C, Shaffrey CI, Chapman JR, Eyre DR. The association of lumbar spondylolisthesis with collagen IX tryptophan alleles. J Bone Joint Surg Br. 2004 Sep;86(7):1021–1026.

Published In

J Bone Joint Surg Br

DOI

ISSN

0301-620X

Publication Date

September 2004

Volume

86

Issue

7

Start / End Page

1021 / 1026

Location

England

Related Subject Headings

  • Tryptophan
  • Spondylolisthesis
  • Spinal Stenosis
  • Risk Factors
  • Radiography
  • Polymorphism, Genetic
  • Orthopedics
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging