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The role of angiotensin II in stress urinary incontinence: A rat model.

Publication ,  Conference
Phull, H; Salkini, M; Escobar, C; Purves, T; Comiter, CV
Published in: Neurourol Urodyn
2007

AIMS: Pharmacological treatment for stress urinary incontinence (SUI) is limited to the use of non-selective alpha-agonists, which are often ineffective. Non-adrenergic mechanisms have also been implicated in urethral closure, including angiotensin II (Ang-II), which has been demonstrated throughout the urinary tract. We investigate the role of Ang-II in urethral tone in a rat model of SUI. METHODS: Abdominal leak point pressure (ALPP) and retrograde urethral pressure profilometry (RLPP) were measured in 70 female virgin rats. Thirty rats underwent pudendal nerve injury (PNT), 30 had circumferential urethrolysis (U-Lys), and 10 had sham surgery. Rats received daily doses of Angiotensin Type 1 (AT-1) receptor inhibitor (20 mg/kg), Angiotensin Type 2 (AT-2) receptor antagonist (10 mg/kg), or Ang-II (2 mg/kg). RESULTS: Following U-Lys, RLPP and ALPP decreased from 21.4 +/- 2.0 and 39.2 +/- 3.3 mm Hg, to 13.1 +/- 1.5 and 21.6 +/- 1.9 mmHg, respectively (P < 0.01). After PNT, RLPP, and ALPP decreased from 21.0 +/- 1.6 and 41.9 +/- 3.0 mmHg to 13.1 +/- 1.5 and 24.7 +/- 3.3 mmHg, respectively (P < 0.01). AT-1 inhibitor caused significant decrease in RLPP and ALPP from 21.0 +/- 6.2 and 41.8 +/- 9.4 mmHg, to 12.0 +/- 3.8 and 25.6 +/- 6.6 mmHg, respectively (P < 0.01). Likewise, AT-2 treatment reduced RLPP and ALPP from 21.4 +/- 6.3 and 40.1 +/- 1.7 mmHg, to 13.5 +/- 5.7 and 31.0 +/- 7.2 mmHg, respectively (P < 0.01). Following surgery, Ang-II administration restored RLPP and ALPP to baseline presurgical values. CONCLUSIONS: AT-1 and AT-2 receptor inhibition significantly lowers urethral resistance, comparable to either neurogenic or urethrolytic injury. Ang-II treatment restored urethral tone in rats with intrinsic sphincter dysfunction. Ang II appears to serve a functional role in the maintenance of urethral tone and stress continence.

Duke Scholars

Published In

Neurourol Urodyn

DOI

ISSN

0733-2467

Publication Date

2007

Volume

26

Issue

1

Start / End Page

81 / 88

Location

United States

Related Subject Headings

  • Vasoconstrictor Agents
  • Urology & Nephrology
  • Urinary Incontinence, Stress
  • Urinary Bladder
  • Urethra
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Rats, Sprague-Dawley
  • Rats
  • Pyridines
 

Citation

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Phull, H., Salkini, M., Escobar, C., Purves, T., & Comiter, C. V. (2007). The role of angiotensin II in stress urinary incontinence: A rat model. In Neurourol Urodyn (Vol. 26, pp. 81–88). United States. https://doi.org/10.1002/nau.20339
Phull, Hardeep, Mohamad Salkini, Christina Escobar, Todd Purves, and Craig V. Comiter. “The role of angiotensin II in stress urinary incontinence: A rat model.” In Neurourol Urodyn, 26:81–88, 2007. https://doi.org/10.1002/nau.20339.
Phull H, Salkini M, Escobar C, Purves T, Comiter CV. The role of angiotensin II in stress urinary incontinence: A rat model. In: Neurourol Urodyn. 2007. p. 81–8.
Phull, Hardeep, et al. “The role of angiotensin II in stress urinary incontinence: A rat model.Neurourol Urodyn, vol. 26, no. 1, 2007, pp. 81–88. Pubmed, doi:10.1002/nau.20339.
Phull H, Salkini M, Escobar C, Purves T, Comiter CV. The role of angiotensin II in stress urinary incontinence: A rat model. Neurourol Urodyn. 2007. p. 81–88.
Journal cover image

Published In

Neurourol Urodyn

DOI

ISSN

0733-2467

Publication Date

2007

Volume

26

Issue

1

Start / End Page

81 / 88

Location

United States

Related Subject Headings

  • Vasoconstrictor Agents
  • Urology & Nephrology
  • Urinary Incontinence, Stress
  • Urinary Bladder
  • Urethra
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Rats, Sprague-Dawley
  • Rats
  • Pyridines