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Editing the Epigenome: Reshaping the Genomic Landscape.

Publication ,  Book
Holtzman, L; Gersbach, CA
August 2018

The eukaryotic epigenome has an instrumental role in determining and maintaining cell identity and function. Epigenetic components such as DNA methylation, histone tail modifications, chromatin accessibility, and DNA architecture are tightly correlated with central cellular processes, while their dysregulation manifests in aberrant gene expression and disease. The ability to specifically edit the epigenome holds the promise of enhancing understanding of how epigenetic modifications function and enabling manipulation of cell phenotype for research or therapeutic purposes. Genome engineering technologies use highly specific DNA-targeting tools to precisely deposit epigenetic changes in a locus-specific manner, creating diverse epigenome editing platforms. This review summarizes these technologies and insights from recent studies, describes the complex relationship between epigenetic components and gene regulation, and highlights caveats and promises of the emerging field of epigenome editing, including applications for translational purposes, such as epigenetic therapy and regenerative medicine.

Duke Scholars

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DOI

Publication Date

August 2018

Volume

19

Start / End Page

43 / 71

Related Subject Headings

  • Protein Processing, Post-Translational
  • Humans
  • Histone Code
  • Genome
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Gene Expression Regulation
  • Gene Editing
  • Epigenomics
  • DNA Methylation
 

Citation

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Holtzman, L., & Gersbach, C. A. (2018). Editing the Epigenome: Reshaping the Genomic Landscape. (Vol. 19, pp. 43–71). https://doi.org/10.1146/annurev-genom-083117-021632
Holtzman, Liad, and Charles A. Gersbach. Editing the Epigenome: Reshaping the Genomic Landscape. Vol. 19, 2018. https://doi.org/10.1146/annurev-genom-083117-021632.
Holtzman L, Gersbach CA. Editing the Epigenome: Reshaping the Genomic Landscape. Vol. 19. 2018.
Holtzman, Liad, and Charles A. Gersbach. Editing the Epigenome: Reshaping the Genomic Landscape. Vol. 19, 2018, pp. 43–71. Epmc, doi:10.1146/annurev-genom-083117-021632.
Holtzman L, Gersbach CA. Editing the Epigenome: Reshaping the Genomic Landscape. 2018. p. 43–71.

DOI

Publication Date

August 2018

Volume

19

Start / End Page

43 / 71

Related Subject Headings

  • Protein Processing, Post-Translational
  • Humans
  • Histone Code
  • Genome
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Gene Expression Regulation
  • Gene Editing
  • Epigenomics
  • DNA Methylation