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A polygenic p factor for major psychiatric disorders.

Publication ,  Journal Article
Selzam, S; Coleman, JRI; Caspi, A; Moffitt, TE; Plomin, R
Published in: Translational psychiatry
October 2018

It has recently been proposed that a single dimension, called the p factor, can capture a person's liability to mental disorder. Relevant to the p hypothesis, recent genetic research has found surprisingly high genetic correlations between pairs of psychiatric disorders. Here, for the first time, we compare genetic correlations from different methods and examine their support for a genetic p factor. We tested the hypothesis of a genetic p factor by applying principal component analysis to matrices of genetic correlations between major psychiatric disorders estimated by three methods-family study, genome-wide complex trait analysis, and linkage-disequilibrium score regression-and on a matrix of polygenic score correlations constructed for each individual in a UK-representative sample of 7 026 unrelated individuals. All disorders loaded positively on a first unrotated principal component, which accounted for 57, 43, 35, and 22% of the variance respectively for the four methods. Our results showed that all four methods provided strong support for a genetic p factor that represents the pinnacle of the hierarchical genetic architecture of psychopathology.

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Published In

Translational psychiatry

DOI

EISSN

2158-3188

ISSN

2158-3188

Publication Date

October 2018

Volume

8

Issue

1

Start / End Page

205

Related Subject Headings

  • Twins
  • Principal Component Analysis
  • Multifactorial Inheritance
  • Mental Disorders
  • Humans
  • Genetic Predisposition to Disease
  • Cohort Studies
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

APA
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ICMJE
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Selzam, S., Coleman, J. R. I., Caspi, A., Moffitt, T. E., & Plomin, R. (2018). A polygenic p factor for major psychiatric disorders. Translational Psychiatry, 8(1), 205. https://doi.org/10.1038/s41398-018-0217-4
Selzam, Saskia, Jonathan R. I. Coleman, Avshalom Caspi, Terrie E. Moffitt, and Robert Plomin. “A polygenic p factor for major psychiatric disorders.Translational Psychiatry 8, no. 1 (October 2018): 205. https://doi.org/10.1038/s41398-018-0217-4.
Selzam S, Coleman JRI, Caspi A, Moffitt TE, Plomin R. A polygenic p factor for major psychiatric disorders. Translational psychiatry. 2018 Oct;8(1):205.
Selzam, Saskia, et al. “A polygenic p factor for major psychiatric disorders.Translational Psychiatry, vol. 8, no. 1, Oct. 2018, p. 205. Epmc, doi:10.1038/s41398-018-0217-4.
Selzam S, Coleman JRI, Caspi A, Moffitt TE, Plomin R. A polygenic p factor for major psychiatric disorders. Translational psychiatry. 2018 Oct;8(1):205.

Published In

Translational psychiatry

DOI

EISSN

2158-3188

ISSN

2158-3188

Publication Date

October 2018

Volume

8

Issue

1

Start / End Page

205

Related Subject Headings

  • Twins
  • Principal Component Analysis
  • Multifactorial Inheritance
  • Mental Disorders
  • Humans
  • Genetic Predisposition to Disease
  • Cohort Studies
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences