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Pancreatic Cancer

Emerging therapeutic targets in pancreatic adenocarcinoma

Publication ,  Chapter
Choe, JH; Abbruzzese, JL
April 11, 2018

Pancreatic adenocarcinoma is one of the most lethal cancers but has limited therapeutic options necessitating continued investigation of new therapeutic agents. Recently, improved overall survival has been achieved with cytotoxic drug combinations including 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) and gemcitabine/nab-paclitaxel, but the success has been modest at best. More targeted approaches focusing on EGFR and MAPK signaling have also enjoyed marginal success. Accumulating evidence suggests that pancreatic tumors have increased dependence on metabolic pathways through both KRAS and KRAS-independent mechanisms and are broadly resistant to drug therapy due to stromal remodeling. Genetic and epigenetic vulnerabilities, such as inactivating aberrations in DNA damage repair, chromatin remodeling, and microRNA dysregulation, may reveal exploitable weaknesses. Modern approaches to drug development tailored to molecularly defined subsets of patients likely to respond to targeted therapies are needed to achieve more substantial progress in this disease in an era of precision medicine.

Duke Scholars

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Publication Date

April 11, 2018

Start / End Page

1613 / 1641
 

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Choe, J. H., & Abbruzzese, J. L. (2018). Emerging therapeutic targets in pancreatic adenocarcinoma. In Pancreatic Cancer (pp. 1613–1641). https://doi.org/10.1007/978-1-4939-7193-0_92
Choe, J. H., and J. L. Abbruzzese. “Emerging therapeutic targets in pancreatic adenocarcinoma.” In Pancreatic Cancer, 1613–41, 2018. https://doi.org/10.1007/978-1-4939-7193-0_92.
Choe JH, Abbruzzese JL. Emerging therapeutic targets in pancreatic adenocarcinoma. In: Pancreatic Cancer. 2018. p. 1613–41.
Choe, J. H., and J. L. Abbruzzese. “Emerging therapeutic targets in pancreatic adenocarcinoma.” Pancreatic Cancer, 2018, pp. 1613–41. Scopus, doi:10.1007/978-1-4939-7193-0_92.
Choe JH, Abbruzzese JL. Emerging therapeutic targets in pancreatic adenocarcinoma. Pancreatic Cancer. 2018. p. 1613–1641.

DOI

Publication Date

April 11, 2018

Start / End Page

1613 / 1641