Tocilizumab in Refractory Autoimmune Encephalitis: A Series of Pediatric Cases.
Publication
, Journal Article
Randell, RL; Adams, AV; Van Mater, H
Published in: Pediatr Neurol
September 2018
BACKGROUND: Autoimmune encephalitis can result in significant neurological and psychiatric morbidity and mortality in patients of all ages and often does not respond to standard therapies. Recent reports suggest efficacy of tocilizumab, a monoclonal antibody against interleukin 6, in refractory autoimmune encephalitis. RESULTS: We describe three children with refractory autoimmune encephalitis who experienced a robust, immediate clinical response following treatment with tocilizumab. CONCLUSION: These findings support the efficacy and short-term safety of tocilizumab as a third-line treatment for refractory autoimmune encephalitis in children.
Duke Scholars
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Published In
Pediatr Neurol
DOI
EISSN
1873-5150
Publication Date
September 2018
Volume
86
Start / End Page
66 / 68
Location
United States
Related Subject Headings
- Neurology & Neurosurgery
- Male
- Immunologic Factors
- Humans
- Hashimoto Disease
- Female
- Encephalitis
- Drug Resistance
- Child
- Antibodies, Monoclonal, Humanized
Citation
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Chicago
ICMJE
MLA
NLM
Randell, R. L., Adams, A. V., & Van Mater, H. (2018). Tocilizumab in Refractory Autoimmune Encephalitis: A Series of Pediatric Cases. Pediatr Neurol, 86, 66–68. https://doi.org/10.1016/j.pediatrneurol.2018.07.016
Randell, Rachel L., Ashley V. Adams, and Heather Van Mater. “Tocilizumab in Refractory Autoimmune Encephalitis: A Series of Pediatric Cases.” Pediatr Neurol 86 (September 2018): 66–68. https://doi.org/10.1016/j.pediatrneurol.2018.07.016.
Randell RL, Adams AV, Van Mater H. Tocilizumab in Refractory Autoimmune Encephalitis: A Series of Pediatric Cases. Pediatr Neurol. 2018 Sep;86:66–8.
Randell, Rachel L., et al. “Tocilizumab in Refractory Autoimmune Encephalitis: A Series of Pediatric Cases.” Pediatr Neurol, vol. 86, Sept. 2018, pp. 66–68. Pubmed, doi:10.1016/j.pediatrneurol.2018.07.016.
Randell RL, Adams AV, Van Mater H. Tocilizumab in Refractory Autoimmune Encephalitis: A Series of Pediatric Cases. Pediatr Neurol. 2018 Sep;86:66–68.
Published In
Pediatr Neurol
DOI
EISSN
1873-5150
Publication Date
September 2018
Volume
86
Start / End Page
66 / 68
Location
United States
Related Subject Headings
- Neurology & Neurosurgery
- Male
- Immunologic Factors
- Humans
- Hashimoto Disease
- Female
- Encephalitis
- Drug Resistance
- Child
- Antibodies, Monoclonal, Humanized