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Injectable and spatially patterned microporous annealed particle (MAP) hydrogels for tissue repair applications

Publication ,  Journal Article
Darling, N; Sideris, E; Hamada, N; Segura, T
Published in: Advanced Science
October 11, 2018

Spatially patterned hydrogels are becoming increasingly popular in the field of regenerative medicine and tissue repair because of their ability to guide cell infiltration and migration. However, postfabrication technologies are usually required to spatially pattern a hydrogel, making these hydrogels difficult to translate into the clinic. Here, an injectable spatially patterned hydrogel is reported using hyaluronic acid (HA)‐based particle hydrogels. These particle hydrogels are sequentially loaded into a syringe to form a pattern and, once injected, they maintain the pattern. The applicability of this hydrogel in a wound healing skin model, a subcutaneous implant model, as well as a stroke brain model is examined and distinct patterning in all models tested is shown. This injectable and spatially patterned hydrogel can be used to create physical or biochemical gradients. Further, this design can better match the scaffold properties within the physical location of the tissue (e.g., wound border vs wound center). This allows for better design features within the material that promote repair and regeneration.

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Published In

Advanced Science

DOI

ISSN

2198-3844

Publication Date

October 11, 2018

Start / End Page

1 / 8

Publisher

Wiley Open Access
 

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Darling, N., Sideris, E., Hamada, N., & Segura, T. (2018). Injectable and spatially patterned microporous annealed particle (MAP) hydrogels for tissue repair applications. Advanced Science, 1–8. https://doi.org/10.1002/advs.201801046
Darling, Nicole, Elias Sideris, Naomi Hamada, and Tatiana Segura. “Injectable and spatially patterned microporous annealed particle (MAP) hydrogels for tissue repair applications.” Advanced Science, October 11, 2018, 1–8. https://doi.org/10.1002/advs.201801046.
Darling N, Sideris E, Hamada N, Segura T. Injectable and spatially patterned microporous annealed particle (MAP) hydrogels for tissue repair applications. Advanced Science. 2018 Oct 11;1–8.
Darling, Nicole, et al. “Injectable and spatially patterned microporous annealed particle (MAP) hydrogels for tissue repair applications.” Advanced Science, Wiley Open Access, Oct. 2018, pp. 1–8. Manual, doi:10.1002/advs.201801046.
Darling N, Sideris E, Hamada N, Segura T. Injectable and spatially patterned microporous annealed particle (MAP) hydrogels for tissue repair applications. Advanced Science. Wiley Open Access; 2018 Oct 11;1–8.
Journal cover image

Published In

Advanced Science

DOI

ISSN

2198-3844

Publication Date

October 11, 2018

Start / End Page

1 / 8

Publisher

Wiley Open Access