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Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study.

Publication ,  Journal Article
Huang, L; Kutch, JJ; Ellingson, BM; Martucci, KT; Harris, RE; Clauw, DJ; Mackey, S; Mayer, EA; Schaeffer, AJ; Apkarian, AV; Farmer, MA ...
Published in: Pain
December 2016

Clinical phenotyping of urological chronic pelvic pain syndromes (UCPPSs) in men and women have focused on end organ abnormalities to identify putative clinical subtypes. Initial evidence of abnormal brain function and structure in male pelvic pain has necessitated large-scale, multisite investigations into potential UCPPS brain biomarkers. We present the first evidence of regional white matter (axonal) abnormalities in men and women with UCPPS, compared with positive (irritable bowel syndrome, IBS) and healthy controls. Epidemiological and neuroimaging data were collected from participants with UCPPS (n = 52), IBS (n = 39), and healthy sex- and age-matched controls (n = 61). White matter microstructure, measured as fractional anisotropy (FA), was examined by diffusion tensor imaging. Group differences in regional FA positively correlated with pain severity, including segments of the right corticospinal tract and right anterior thalamic radiation. Increased corticospinal FA was specific and sensitive to UCPPS, positively correlated with pain severity, and reflected sensory (not affective) features of pain. Reduced anterior thalamic radiation FA distinguished patients with IBS from those with UCPPS and controls, suggesting greater microstructural divergence from normal tract organization. Findings confirm that regional white matter abnormalities characterize UCPPS and can distinguish between visceral diagnoses, suggesting that regional axonal microstructure is either altered with ongoing pain or predisposes its development.

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Published In

Pain

DOI

EISSN

1872-6623

Publication Date

December 2016

Volume

157

Issue

12

Start / End Page

2782 / 2791

Location

United States

Related Subject Headings

  • White Matter
  • Retrospective Studies
  • Pelvic Pain
  • Male
  • Irritable Bowel Syndrome
  • Imaging, Three-Dimensional
  • Humans
  • Female
  • Diffusion Tensor Imaging
  • Case-Control Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huang, L., Kutch, J. J., Ellingson, B. M., Martucci, K. T., Harris, R. E., Clauw, D. J., … MAPP Research Network, . (2016). Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study. Pain, 157(12), 2782–2791. https://doi.org/10.1097/j.pain.0000000000000703
Huang, Lejian, Jason J. Kutch, Benjamin M. Ellingson, Katherine T. Martucci, Richard E. Harris, Daniel J. Clauw, Sean Mackey, et al. “Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study.Pain 157, no. 12 (December 2016): 2782–91. https://doi.org/10.1097/j.pain.0000000000000703.
Huang L, Kutch JJ, Ellingson BM, Martucci KT, Harris RE, Clauw DJ, et al. Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study. Pain. 2016 Dec;157(12):2782–91.
Huang, Lejian, et al. “Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study.Pain, vol. 157, no. 12, Dec. 2016, pp. 2782–91. Pubmed, doi:10.1097/j.pain.0000000000000703.
Huang L, Kutch JJ, Ellingson BM, Martucci KT, Harris RE, Clauw DJ, Mackey S, Mayer EA, Schaeffer AJ, Apkarian AV, Farmer MA, MAPP Research Network. Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study. Pain. 2016 Dec;157(12):2782–2791.

Published In

Pain

DOI

EISSN

1872-6623

Publication Date

December 2016

Volume

157

Issue

12

Start / End Page

2782 / 2791

Location

United States

Related Subject Headings

  • White Matter
  • Retrospective Studies
  • Pelvic Pain
  • Male
  • Irritable Bowel Syndrome
  • Imaging, Three-Dimensional
  • Humans
  • Female
  • Diffusion Tensor Imaging
  • Case-Control Studies