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Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.

Publication ,  Journal Article
Massberg, S; Schaerli, P; Knezevic-Maramica, I; Köllnberger, M; Tubo, N; Moseman, EA; Huff, IV; Junt, T; Wagers, AJ; Mazo, IB; von Andrian, UH
Published in: Cell
November 30, 2007

Constitutive egress of bone marrow (BM)-resident hematopoietic stem and progenitor cells (HSPCs) into the blood is a well-established phenomenon, but the ultimate fate and functional relevance of circulating HSPCs is largely unknown. We show that mouse thoracic duct (TD) lymph contains HSPCs that possess short- and long-term multilineage reconstitution capacity. TD-derived HSPCs originate in the BM, enter the blood, and traffic to multiple peripheral organs, where they reside for at least 36 hr before entering draining lymphatics to return to the blood and, eventually, the BM. HSPC egress from extramedullary tissues into lymph depends on sphingosine-1-phosphate receptors. Migratory HSPCs proliferate within extramedullary tissues and give rise to tissue-resident myeloid cells, preferentially dendritic cells. HSPC differentiation is amplified upon exposure to Toll-like receptor agonists. Thus, HSPCs can survey peripheral organs and can foster the local production of tissue-resident innate immune cells under both steady-state conditions and in response to inflammatory signals.

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Published In

Cell

DOI

ISSN

0092-8674

Publication Date

November 30, 2007

Volume

131

Issue

5

Start / End Page

994 / 1008

Location

United States

Related Subject Headings

  • Thoracic Duct
  • Receptors, Lysosphingolipid
  • Proto-Oncogene Proteins c-kit
  • Models, Biological
  • Mice, Transgenic
  • Mice, Nude
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Lymphatic System
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Massberg, S., Schaerli, P., Knezevic-Maramica, I., Köllnberger, M., Tubo, N., Moseman, E. A., … von Andrian, U. H. (2007). Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell, 131(5), 994–1008. https://doi.org/10.1016/j.cell.2007.09.047
Massberg, Steffen, Patrick Schaerli, Irina Knezevic-Maramica, Maria Köllnberger, Noah Tubo, E Ashley Moseman, Ines V. Huff, et al. “Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.Cell 131, no. 5 (November 30, 2007): 994–1008. https://doi.org/10.1016/j.cell.2007.09.047.
Massberg S, Schaerli P, Knezevic-Maramica I, Köllnberger M, Tubo N, Moseman EA, et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell. 2007 Nov 30;131(5):994–1008.
Massberg, Steffen, et al. “Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues.Cell, vol. 131, no. 5, Nov. 2007, pp. 994–1008. Pubmed, doi:10.1016/j.cell.2007.09.047.
Massberg S, Schaerli P, Knezevic-Maramica I, Köllnberger M, Tubo N, Moseman EA, Huff IV, Junt T, Wagers AJ, Mazo IB, von Andrian UH. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell. 2007 Nov 30;131(5):994–1008.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

November 30, 2007

Volume

131

Issue

5

Start / End Page

994 / 1008

Location

United States

Related Subject Headings

  • Thoracic Duct
  • Receptors, Lysosphingolipid
  • Proto-Oncogene Proteins c-kit
  • Models, Biological
  • Mice, Transgenic
  • Mice, Nude
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Lymphatic System