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MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management.

Publication ,  Journal Article
Bellot, GL; Dong, X; Lahiri, A; Sebastin, SJ; Batinic-Haberle, I; Pervaiz, S; Puhaindran, ME
Published in: Redox Biol
January 2019

Negative Pressure Wound Therapy (NPWT), a widely used modality in the management of surgical and trauma wounds, offers clear benefits over conventional wound healing strategies. Despite the wide-ranging effects ascribed to NPWT, the precise molecular mechanisms underlying the accelerated healing supported by NPWT remains poorly understood. Notably, cellular redox status-a product of the balance between cellular reactive oxygen species (ROS) production and anti-oxidant defense systems-plays an important role in wound healing and dysregulation of redox homeostasis has a profound effect on wound healing. Here we investigated potential links between the use of NPWT and the regulation of antioxidant mechanisms. Using patient samples and a rodent model of acute injury, we observed a significant accumulation of MnSOD protein as well as higher enzymatic activity in tissues upon NPWT. As a proof of concept and to outline the important role of SOD activity in wound healing, we replaced NPWT by the topical application of a MnSOD mimetic, Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP5+, MnE, BMX-010, AEOl10113) in the rodent model. We observed that MnE is a potent wound healing enhancer as it appears to facilitate the formation of new tissue within the wound bed and consequently advances wound closure by two days, compared to the non-treated animals. Taken together, these results show for the first time a link between NPWT and regulation of antioxidant mechanism through the maintenance of MnSOD activity. Additionally this discovery outlined the potential role of MnSOD mimetics as topical agents enhancing wound healing.

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Published In

Redox Biol

DOI

EISSN

2213-2317

Publication Date

January 2019

Volume

20

Start / End Page

307 / 320

Location

Netherlands

Related Subject Headings

  • Wound Healing
  • Treatment Outcome
  • Superoxide Dismutase
  • Rats
  • Negative-Pressure Wound Therapy
  • Metalloporphyrins
  • Humans
  • Enzyme Activation
  • Disease Models, Animal
  • Disease Management
 

Citation

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Bellot, G. L., Dong, X., Lahiri, A., Sebastin, S. J., Batinic-Haberle, I., Pervaiz, S., & Puhaindran, M. E. (2019). MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management. Redox Biol, 20, 307–320. https://doi.org/10.1016/j.redox.2018.10.014
Bellot, Gregory Lucien, Xiaoke Dong, Amitabha Lahiri, Sandeep Jacob Sebastin, Ines Batinic-Haberle, Shazib Pervaiz, and Mark Edward Puhaindran. “MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management.Redox Biol 20 (January 2019): 307–20. https://doi.org/10.1016/j.redox.2018.10.014.
Bellot GL, Dong X, Lahiri A, Sebastin SJ, Batinic-Haberle I, Pervaiz S, et al. MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management. Redox Biol. 2019 Jan;20:307–20.
Bellot, Gregory Lucien, et al. “MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management.Redox Biol, vol. 20, Jan. 2019, pp. 307–20. Pubmed, doi:10.1016/j.redox.2018.10.014.
Bellot GL, Dong X, Lahiri A, Sebastin SJ, Batinic-Haberle I, Pervaiz S, Puhaindran ME. MnSOD is implicated in accelerated wound healing upon Negative Pressure Wound Therapy (NPWT): A case in point for MnSOD mimetics as adjuvants for wound management. Redox Biol. 2019 Jan;20:307–320.
Journal cover image

Published In

Redox Biol

DOI

EISSN

2213-2317

Publication Date

January 2019

Volume

20

Start / End Page

307 / 320

Location

Netherlands

Related Subject Headings

  • Wound Healing
  • Treatment Outcome
  • Superoxide Dismutase
  • Rats
  • Negative-Pressure Wound Therapy
  • Metalloporphyrins
  • Humans
  • Enzyme Activation
  • Disease Models, Animal
  • Disease Management