Scholars@Duke publication: Adjunctive perampanel for glioma-associated epilepsy.

Adjunctive perampanel for glioma-associated epilepsy.

Publication , Journal Article

Dunn-Pirio, AM; Woodring, S; Lipp, E; Herndon, JE; Healy, P; Weant, M; Randazzo, D; Desjardins, A; Friedman, HS; Peters, KB

Published in: Epilepsy Behav Case Rep

2018

Published version (DOI) Link to item

Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy. We conducted a single-arm study of adjunctive perampanel for patients with focal-onset glioma-associated seizures. The most common related adverse events were fatigue and dizziness. Three out of 8 participants had self-reported seizure reduction and an additional 3 reported improved control. Of these 6, 5 had isocitrate dehydrogenase 1 mutant gliomas. We conclude that perampanel is safe for patients with glioma-related focal-onset epilepsy. Further study into the association between AMPA signaling, IDH1 status and seizures is warranted.

Duke Scholars

Author James Emmett Herndon II Biostatistics & Bioinformatics, Division of Biostatistics

Author Annick Desjardins Neurosurgery, Neuro-Oncology

Author Henry Seth Friedman Neurosurgery, Neuro-Oncology

Author Katherine Barnett Peters Neurosurgery, Neuro-Oncology

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Published In

Epilepsy Behav Case Rep

DOI

10.1016/j.ebcr.2018.09.003

ISSN

2213-3232

Publication Date

2018

Volume

Start / End Page

114 / 117

Location

United States

Citation

APA

Chicago

ICMJE

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Dunn-Pirio, A. M., Woodring, S., Lipp, E., Herndon, J. E., Healy, P., Weant, M., … Peters, K. B. (2018). Adjunctive perampanel for glioma-associated epilepsy. Epilepsy Behav Case Rep, 10, 114–117. https://doi.org/10.1016/j.ebcr.2018.09.003

Dunn-Pirio, Anastasie M., Sarah Woodring, Eric Lipp, James E. Herndon, Patrick Healy, Mallika Weant, Dina Randazzo, Annick Desjardins, Henry S. Friedman, and Katherine B. Peters. “Adjunctive perampanel for glioma-associated epilepsy.” Epilepsy Behav Case Rep 10 (2018): 114–17. https://doi.org/10.1016/j.ebcr.2018.09.003.

Dunn-Pirio AM, Woodring S, Lipp E, Herndon JE, Healy P, Weant M, et al. Adjunctive perampanel for glioma-associated epilepsy. Epilepsy Behav Case Rep. 2018;10:114–7.

Dunn-Pirio, Anastasie M., et al. “Adjunctive perampanel for glioma-associated epilepsy.” Epilepsy Behav Case Rep, vol. 10, 2018, pp. 114–17. Pubmed, doi:10.1016/j.ebcr.2018.09.003.

Dunn-Pirio AM, Woodring S, Lipp E, Herndon JE, Healy P, Weant M, Randazzo D, Desjardins A, Friedman HS, Peters KB. Adjunctive perampanel for glioma-associated epilepsy. Epilepsy Behav Case Rep. 2018;10:114–117.

Published In

Epilepsy Behav Case Rep

DOI

10.1016/j.ebcr.2018.09.003

ISSN

2213-3232

Publication Date

2018

Volume

Start / End Page

114 / 117

Location

United States