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Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs.

Publication ,  Journal Article
Fang, Z; Huang, C; Zhang, JJ; Xie, J; Dai, S; Ge, E; Xiang, J; Yao, H; Huang, R; Bi, X; Wang, B; Zhong, N; Lai, K
Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
March 2019

The pathogenesis and pathophysiology of eosinophilia-related chronic cough such as non-asthmatic eosinophilic bronchitis and cough variant asthma are still not clear.This study is to examine the potential role of traffic-related air pollution (TRAP) in eosinophilic inflammation and cough responses.Non-sensitized guinea-pigs were exposed to TRAP in an urban traffic tunnel or kept in a filtered air environment for 7 or 14 days. Reflexive cough was measured using citric acid and allyl isothiocyanate (AITC) challenges, respectively. Spontaneous cough counting was determined using audio recording and a waveform analysis. Airway inflammation was evaluated using differential cells in bronchoalveolar lavage fluid (BALF) and lung histopathology. To further elucidate the relationship between airway inflammation and cough hypersensitivity, a subgroup of those exposed for 14 days received a dexamethasone treatment.Compared to reflexive cough count (mean (95% confidence interval) in 10 minutes) provoked by the AITC challenge for the unexposed animals (3.1 (1.7-4.5)), those were increased significantly following both the 7-day (12.0 (6.8-17.2), P < 0.01) and the 14-day (12.0 (6.4-17.6), P < 0.01) TRAP exposure. The effect provoked by the citric acid challenge was more profound following the 14-day exposure (26.0 (19.5-32.5) vs 3.8 (1.5-6.0) for the control, P < 0.001). TRAP exposures enhanced spontaneous cough events, caused a significant increase of eosinophils and neutrophils in BALF and resulted in a dramatic eosinophilic infiltration in submucosal layer of trachea and bronchus, which can be inhibited significantly by dexamethasone treatment.TRAP exposures induced cough hypersensitivity and non-allergic eosinophilic inflammation of airways in guinea-pigs. This study highlights the potential mechanisms of eosinophilia-related chronic cough that can be induced by traffic-related air pollution.

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Published In

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

DOI

EISSN

1365-2222

ISSN

0954-7894

Publication Date

March 2019

Volume

49

Issue

3

Start / End Page

366 / 377

Related Subject Headings

  • Traffic-Related Pollution
  • Male
  • Hypersensitivity
  • Guinea Pigs
  • Female
  • Eosinophils
  • Eosinophilia
  • Environmental Exposure
  • Cough
  • Bronchoalveolar Lavage Fluid
 

Citation

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MLA
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Fang, Z., Huang, C., Zhang, J. J., Xie, J., Dai, S., Ge, E., … Lai, K. (2019). Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 49(3), 366–377. https://doi.org/10.1111/cea.13308
Fang, Zhangfu, Chuqin Huang, Junfeng Jim Zhang, Jiaxing Xie, Shouhui Dai, Erjia Ge, Juan Xiang, et al. “Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs.Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology 49, no. 3 (March 2019): 366–77. https://doi.org/10.1111/cea.13308.
Fang Z, Huang C, Zhang JJ, Xie J, Dai S, Ge E, et al. Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2019 Mar;49(3):366–77.
Fang, Zhangfu, et al. “Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs.Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 49, no. 3, Mar. 2019, pp. 366–77. Epmc, doi:10.1111/cea.13308.
Fang Z, Huang C, Zhang JJ, Xie J, Dai S, Ge E, Xiang J, Yao H, Huang R, Bi X, Wang B, Zhong N, Lai K. Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2019 Mar;49(3):366–377.
Journal cover image

Published In

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

DOI

EISSN

1365-2222

ISSN

0954-7894

Publication Date

March 2019

Volume

49

Issue

3

Start / End Page

366 / 377

Related Subject Headings

  • Traffic-Related Pollution
  • Male
  • Hypersensitivity
  • Guinea Pigs
  • Female
  • Eosinophils
  • Eosinophilia
  • Environmental Exposure
  • Cough
  • Bronchoalveolar Lavage Fluid