Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel
Journal cover image

Rationale and design for a cluster randomized quality-improvement trial to increase the uptake of evidence-based therapies for patients at high cardiovascular risk: The BRIDGE-Cardiovascular Prevention trial.

Publication ,  Journal Article
Machline-Carrion, MJ; Soares, RM; Damiani, LP; Campos, VB; Sampaio, B; Yamashita, J; Fonseca, FH; Izar, MC; Amodeo, C; Pontes-Neto, OM ...
Published in: Am Heart J
January 2019

BACKGROUND: Translating evidence into clinical practice in the management of high cardiovascular risk patients is challenging. Few quality improvement interventions have rigorously evaluated their impact on both patient care and clinical outcomes. OBJECTIVES: The main objectives are to evaluate the impact of a multifaceted educational intervention on adherence to local guidelines for the prescription of statins, antiplatelets and angiotensin converting enzyme inhibitors or angiotensin II receptor blockers for high cardiovascular risk patients, as well as on the incidence of major cardiovascular events. DESIGN: We designed a pragmatic two arm cluster randomized trial involving 40 clusters. Clusters are randomized to receive a multifaceted quality improvement intervention or to routine practice (control). The multifaceted intervention includes: reminders, care algorithms, training of a case manager, audit and feedback reports, and distribution of educational materials to health care providers. The primary endpoint is the adherence to combined evidence-based therapies (statins, antiplatelet therapy and angiotensin converting enzyme inhibitors or angiotensin receptor blockers) at 12 months after the intervention period in patients without contra-indications for these medications. All analyses follow the intention-to-treat principle and take the cluster design into account using linear mixed logistic regression modeling. SUMMARY: If proven effective, this multifaceted intervention would have wide utility as a means of promoting optimal usage of evidence-based interventions for the management of high cardiovascular risk patients.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

January 2019

Volume

207

Start / End Page

40 / 48

Location

United States

Related Subject Headings

  • Risk Factors
  • Research Design
  • Reminder Systems
  • Quality Improvement
  • Platelet Aggregation Inhibitors
  • Medication Adherence
  • Logistic Models
  • Intention to Treat Analysis
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Machline-Carrion, M. J., Soares, R. M., Damiani, L. P., Campos, V. B., Sampaio, B., Yamashita, J., … Berwanger, O. (2019). Rationale and design for a cluster randomized quality-improvement trial to increase the uptake of evidence-based therapies for patients at high cardiovascular risk: The BRIDGE-Cardiovascular Prevention trial. Am Heart J, 207, 40–48. https://doi.org/10.1016/j.ahj.2018.10.001
Machline-Carrion, Maria Julia, Rafael Marques Soares, Lucas Petri Damiani, Viviane Bezerra Campos, Bruna Sampaio, Juliana Yamashita, Francisco H. Fonseca, et al. “Rationale and design for a cluster randomized quality-improvement trial to increase the uptake of evidence-based therapies for patients at high cardiovascular risk: The BRIDGE-Cardiovascular Prevention trial.Am Heart J 207 (January 2019): 40–48. https://doi.org/10.1016/j.ahj.2018.10.001.
Machline-Carrion MJ, Soares RM, Damiani LP, Campos VB, Sampaio B, Yamashita J, Fonseca FH, Izar MC, Amodeo C, Pontes-Neto OM, de Melo Barros PG, Lopes RD, Brandão da Silva N, Guimarães HP, Piegas L, Stein AT, Berwanger O. Rationale and design for a cluster randomized quality-improvement trial to increase the uptake of evidence-based therapies for patients at high cardiovascular risk: The BRIDGE-Cardiovascular Prevention trial. Am Heart J. 2019 Jan;207:40–48.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

January 2019

Volume

207

Start / End Page

40 / 48

Location

United States

Related Subject Headings

  • Risk Factors
  • Research Design
  • Reminder Systems
  • Quality Improvement
  • Platelet Aggregation Inhibitors
  • Medication Adherence
  • Logistic Models
  • Intention to Treat Analysis
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans