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Neutrophilic figurate erythema of infancy: A diagnostic challenge.

Publication ,  Journal Article
Hamidi, S; Prose, NS; Selim, MA
Published in: J Cutan Pathol
March 2019

Neutrophilic figurate erythema of infancy (NFEI) is a rare variant of annular erythema of infancy. It is characterized by annular erythematous plaques, occasionally with a polycyclic configuration. The main challenge is to differentiate this rare entity from other figurate erythemas associated with serious diseases such as neonatal lupus erythematosus. We present the case of a 9-month-old female admitted with a skin rash of unclear etiology. The rash started on her face at the age of 3 months and gradually spread to her extremities. She had no constitutional symptoms, and her health and development were otherwise unremarkable since birth. This persistent skin eruption consisted of many ill-defined erythematous papules and annular plaques. Histologic examination revealed perivascular neutrophils and eosinophils with abundant nuclear dust without signs of vasculitis. NFEI is a diagnostic enigma both clinically and histologically. Absence of an underlying cause, dermal neutrophilic infiltrate with leukocytoclasis, and lack of vascular damage are the keys to diagnosis.

Duke Scholars

Published In

J Cutan Pathol

DOI

EISSN

1600-0560

Publication Date

March 2019

Volume

46

Issue

3

Start / End Page

216 / 220

Location

United States

Related Subject Headings

  • Skin Diseases, Genetic
  • Neutrophils
  • Infant
  • Humans
  • Female
  • Erythema
  • Eosinophils
  • Dermatology & Venereal Diseases
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
MLA
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Hamidi, S., Prose, N. S., & Selim, M. A. (2019). Neutrophilic figurate erythema of infancy: A diagnostic challenge. J Cutan Pathol, 46(3), 216–220. https://doi.org/10.1111/cup.13394
Hamidi, Sepehr, Neil S. Prose, and Maria A. Selim. “Neutrophilic figurate erythema of infancy: A diagnostic challenge.J Cutan Pathol 46, no. 3 (March 2019): 216–20. https://doi.org/10.1111/cup.13394.
Hamidi S, Prose NS, Selim MA. Neutrophilic figurate erythema of infancy: A diagnostic challenge. J Cutan Pathol. 2019 Mar;46(3):216–20.
Hamidi, Sepehr, et al. “Neutrophilic figurate erythema of infancy: A diagnostic challenge.J Cutan Pathol, vol. 46, no. 3, Mar. 2019, pp. 216–20. Pubmed, doi:10.1111/cup.13394.
Hamidi S, Prose NS, Selim MA. Neutrophilic figurate erythema of infancy: A diagnostic challenge. J Cutan Pathol. 2019 Mar;46(3):216–220.
Journal cover image

Published In

J Cutan Pathol

DOI

EISSN

1600-0560

Publication Date

March 2019

Volume

46

Issue

3

Start / End Page

216 / 220

Location

United States

Related Subject Headings

  • Skin Diseases, Genetic
  • Neutrophils
  • Infant
  • Humans
  • Female
  • Erythema
  • Eosinophils
  • Dermatology & Venereal Diseases
  • 3202 Clinical sciences
  • 1103 Clinical Sciences