Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration.

Publication ,  Journal Article
Riley, L; Schirmer, L; Segura, T
Published in: Current opinion in biotechnology
December 2019

Granular hydrogels are emerging as a versatile and effective platform for tissue engineered constructs in regenerative medicine. The hydrogel microparticles (HMPs) that compose these materials exhibit particle jamming above a minimum packing fraction, which results in a bulk, yet dynamic, granular hydrogel scaffold. These injectable, microporous scaffolds possess self-assembling, shear-thinning, and self-healing properties. Recently, they have been utilized as cell cultures platforms and extracellular matrix mimics with remarkable success in promoting cellular infiltration and subsequent tissue remodeling in vivo. Furthermore, the modular nature of granular hydrogels accommodates heterogeneous HMP assembly, where varying HMPs have been fabricated to target distinct biological processes or deliver unique cargo. Such multifunctional materials offer enormous potential for capturing the structural and biofunctional complexity observed in native human tissue.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

December 2019

Volume

60

Start / End Page

1 / 8

Related Subject Headings

  • Wound Healing
  • Tissue Engineering
  • Regenerative Medicine
  • Hydrogels
  • Humans
  • Extracellular Matrix
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Riley, L., Schirmer, L., & Segura, T. (2019). Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration. Current Opinion in Biotechnology, 60, 1–8. https://doi.org/10.1016/j.copbio.2018.11.001
Riley, Lindsay, Lucas Schirmer, and Tatiana Segura. “Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration.Current Opinion in Biotechnology 60 (December 2019): 1–8. https://doi.org/10.1016/j.copbio.2018.11.001.
Riley, Lindsay, et al. “Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration.Current Opinion in Biotechnology, vol. 60, Dec. 2019, pp. 1–8. Epmc, doi:10.1016/j.copbio.2018.11.001.
Journal cover image

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

December 2019

Volume

60

Start / End Page

1 / 8

Related Subject Headings

  • Wound Healing
  • Tissue Engineering
  • Regenerative Medicine
  • Hydrogels
  • Humans
  • Extracellular Matrix
  • Biotechnology
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology