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SOCE and STIM1 signaling in the heart: Timing and location matter.

Publication ,  Journal Article
Rosenberg, P; Katz, D; Bryson, V
Published in: Cell Calcium
January 2019

Store operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway discovered decades ago, but the function of SOCE in human physiology is only now being revealed. The relevance of this pathway to striated muscle was solidified with the description of skeletal myopathies that result from mutations in STIM1 and Orai1, the two SOCE components. Here, we consider the evidence for STIM1 and SOCE in cardiac muscle and the sinoatrial node. We highlight recent studies revealing a role for STIM1 in cardiac growth in response to developmental and pathologic cues. We also review the role of STIM1 in the regulation of SOCE and Ca2+ store refilling in a non-Orai dependent manner. Finally, we discuss the importance of this pathway in ventricular cardiomyocytes where SOCE contribute to developmental growth and in pacemaker cells where SOCE likely has a fundamental to generating the cardiac rhythm.

Duke Scholars

Published In

Cell Calcium

DOI

EISSN

1532-1991

Publication Date

January 2019

Volume

77

Start / End Page

20 / 28

Location

Netherlands

Related Subject Headings

  • Stromal Interaction Molecule 1
  • Sinoatrial Node
  • ORAI1 Protein
  • Neoplasm Proteins
  • Myocytes, Cardiac
  • Myocardium
  • Humans
  • Calcium Signaling
  • Calcium
  • Biochemistry & Molecular Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rosenberg, P., Katz, D., & Bryson, V. (2019). SOCE and STIM1 signaling in the heart: Timing and location matter. Cell Calcium, 77, 20–28. https://doi.org/10.1016/j.ceca.2018.11.008
Rosenberg, Paul, Danielle Katz, and Victoria Bryson. “SOCE and STIM1 signaling in the heart: Timing and location matter.Cell Calcium 77 (January 2019): 20–28. https://doi.org/10.1016/j.ceca.2018.11.008.
Rosenberg P, Katz D, Bryson V. SOCE and STIM1 signaling in the heart: Timing and location matter. Cell Calcium. 2019 Jan;77:20–8.
Rosenberg, Paul, et al. “SOCE and STIM1 signaling in the heart: Timing and location matter.Cell Calcium, vol. 77, Jan. 2019, pp. 20–28. Pubmed, doi:10.1016/j.ceca.2018.11.008.
Rosenberg P, Katz D, Bryson V. SOCE and STIM1 signaling in the heart: Timing and location matter. Cell Calcium. 2019 Jan;77:20–28.
Journal cover image

Published In

Cell Calcium

DOI

EISSN

1532-1991

Publication Date

January 2019

Volume

77

Start / End Page

20 / 28

Location

Netherlands

Related Subject Headings

  • Stromal Interaction Molecule 1
  • Sinoatrial Node
  • ORAI1 Protein
  • Neoplasm Proteins
  • Myocytes, Cardiac
  • Myocardium
  • Humans
  • Calcium Signaling
  • Calcium
  • Biochemistry & Molecular Biology