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Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension.

Publication ,  Journal Article
Alenezi, F; Mandawat, A; Il'Giovine, ZJ; Shaw, LK; Siddiqui, I; Tapson, VF; Arges, K; Rivera, D; Romano, MMD; Velazquez, EJ; Douglas, PS ...
Published in: Circ Cardiovasc Imaging
November 2018

Background Although right atrial (RA) enlargement is an established marker for adverse outcomes, the prognostic importance of RA dysfunction independent of RA size in pulmonary arterial hypertension is not known. Methods and Results Study subjects with pulmonary arterial hypertension were prospectively enrolled from 2010 to 2014. RA function was measured using RA speckle-tracking longitudinal strain and strain rate (SR) during each phase of the cardiac cycle: (1) RA reservoir (peak longitudinal strain, peak systolic SR), (2) RA conduit (peak early diastolic SR), and (3) RA active contraction (peak active contraction strain, peak contraction SR). The primary outcome was a composite of time to hospitalization or death assessed on follow-up. A total of 63 subjects had complete echocardiographic data. Of these, 91% were females, and the mean age was 58±12 years. During the follow-up period (range: 1-58 months), 39 were hospitalized or had died. After multivariable adjustment for age, sex, and left atrial size, peak longitudinal strain, peak active contraction strain, and peak early diastolic SR were significantly associated with increased risk of the composite outcome ( P=0.0005, P=0.0167, and P=0.0054, respectively). Conclusions RA dysfunction independently predicts mortality and hospitalizations in patients with pulmonary arterial hypertension.

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Published In

Circ Cardiovasc Imaging

DOI

EISSN

1942-0080

Publication Date

November 2018

Volume

11

Issue

11

Start / End Page

e006984

Location

United States

Related Subject Headings

  • Systole
  • Prospective Studies
  • Prognosis
  • Myocardial Contraction
  • Middle Aged
  • Male
  • Hypertension, Pulmonary
  • Humans
  • Heart Atria
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Alenezi, F., Mandawat, A., Il’Giovine, Z. J., Shaw, L. K., Siddiqui, I., Tapson, V. F., … Rajagopal, S. (2018). Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension. Circ Cardiovasc Imaging, 11(11), e006984. https://doi.org/10.1161/CIRCIMAGING.117.006984
Alenezi, Fawaz, Aditya Mandawat, Zachary J. Il’Giovine, Linda K. Shaw, Irfan Siddiqui, Victor F. Tapson, Kristine Arges, et al. “Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension.Circ Cardiovasc Imaging 11, no. 11 (November 2018): e006984. https://doi.org/10.1161/CIRCIMAGING.117.006984.
Alenezi F, Mandawat A, Il’Giovine ZJ, Shaw LK, Siddiqui I, Tapson VF, et al. Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension. Circ Cardiovasc Imaging. 2018 Nov;11(11):e006984.
Alenezi, Fawaz, et al. “Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension.Circ Cardiovasc Imaging, vol. 11, no. 11, Nov. 2018, p. e006984. Pubmed, doi:10.1161/CIRCIMAGING.117.006984.
Alenezi F, Mandawat A, Il’Giovine ZJ, Shaw LK, Siddiqui I, Tapson VF, Arges K, Rivera D, Romano MMD, Velazquez EJ, Douglas PS, Samad Z, Rajagopal S. Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension. Circ Cardiovasc Imaging. 2018 Nov;11(11):e006984.

Published In

Circ Cardiovasc Imaging

DOI

EISSN

1942-0080

Publication Date

November 2018

Volume

11

Issue

11

Start / End Page

e006984

Location

United States

Related Subject Headings

  • Systole
  • Prospective Studies
  • Prognosis
  • Myocardial Contraction
  • Middle Aged
  • Male
  • Hypertension, Pulmonary
  • Humans
  • Heart Atria
  • Follow-Up Studies