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Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features.

Publication ,  Journal Article
Safaee, MM; Jonzzon, S; López, GY; Asaikar, S; Tihan, T; Glenn, OA; Gupta, N
Published in: J Neurosurg Pediatr
November 1, 2018

Calcifying pseudoneoplasms of the neuraxis (CAPNONs) are rare, nonneoplastic lesions of the CNS. Their radiographic features have been well described, with prominent calcifications seen on CT imaging and generally uniform hypointensity on T1- and T2-weighted MRI sequences, with variable patterns of contrast enhancement. They are not associated with significant perilesional edema. The authors present an unusual case of an 8-year-old boy who was found to have a 2.5-cm right frontal mass that demonstrated reduced signal on T2-weighted sequences, heterogeneous contrast enhancement, and extensive perilesional edema on MRI sequences. The differential diagnoses included a chronic infection or neoplasm. He underwent gross-total resection of a firm, calcified mass that had clear boundaries between it and the surrounding gliotic brain. Pathological analysis demonstrated a well-circumscribed lesion with islands of lamellar calcifications and intervening spindle cells, consistent with a CAPNON. At 8 months after surgery the patient remained seizure free, and MRI revealed no evidence of residual lesion and significant improvement in perilesional edema. This particular case highlights the potential for unusual presentation of CAPNON and the rare presence of perilesional edema.

Duke Scholars

Published In

J Neurosurg Pediatr

DOI

EISSN

1933-0715

Publication Date

November 1, 2018

Volume

22

Issue

5

Start / End Page

528 / 531

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Male
  • Humans
  • Edema
  • Child
  • Calcinosis
  • Brain Diseases
  • Brain
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Safaee, M. M., Jonzzon, S., López, G. Y., Asaikar, S., Tihan, T., Glenn, O. A., & Gupta, N. (2018). Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features. J Neurosurg Pediatr, 22(5), 528–531. https://doi.org/10.3171/2018.5.PEDS18104
Safaee, Michael M., Soren Jonzzon, Giselle Y. López, Shailesh Asaikar, Tarik Tihan, Orit A. Glenn, and Nalin Gupta. “Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features.J Neurosurg Pediatr 22, no. 5 (November 1, 2018): 528–31. https://doi.org/10.3171/2018.5.PEDS18104.
Safaee MM, Jonzzon S, López GY, Asaikar S, Tihan T, Glenn OA, et al. Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features. J Neurosurg Pediatr. 2018 Nov 1;22(5):528–31.
Safaee, Michael M., et al. “Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features.J Neurosurg Pediatr, vol. 22, no. 5, Nov. 2018, pp. 528–31. Pubmed, doi:10.3171/2018.5.PEDS18104.
Safaee MM, Jonzzon S, López GY, Asaikar S, Tihan T, Glenn OA, Gupta N. Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features. J Neurosurg Pediatr. 2018 Nov 1;22(5):528–531.

Published In

J Neurosurg Pediatr

DOI

EISSN

1933-0715

Publication Date

November 1, 2018

Volume

22

Issue

5

Start / End Page

528 / 531

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Male
  • Humans
  • Edema
  • Child
  • Calcinosis
  • Brain Diseases
  • Brain
  • 1114 Paediatrics and Reproductive Medicine