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Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation.

Publication ,  Journal Article
Gu, Y; Chen, C; Wang, Z; Huang, P-H; Fu, H; Wang, L; Wu, M; Chen, Y; Gao, T; Gong, J; Kwun, J; Arepally, GM; Huang, TJ
Published in: Lab Chip
January 29, 2019

Platelet separation is a crucial step for both blood donation and treatment of essential thrombocytosis. Here we present an acoustofluidic device that is capable of performing high-throughput, biocompatible platelet separation using sound waves. The device is entirely made of plastic material, which renders the device disposable and more suitable for clinical use. We used this device to process undiluted human whole blood, and we demonstrate a sample throughput of 20 mL min-1, a platelet recovery rate of 87.3%, and a red/white blood cell removal rate of 88.9%. We preserved better platelet function and integrity for isolated platelets than those which are isolated using established methods. Our device features advantages such as rapid fabrication, high throughput, and biocompatibility, so it is a promising alternative to existing platelet separation approaches.

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Published In

Lab Chip

DOI

EISSN

1473-0189

Publication Date

January 29, 2019

Volume

19

Issue

3

Start / End Page

394 / 402

Location

England

Related Subject Headings

  • Plastics
  • Humans
  • Equipment Design
  • Disposable Equipment
  • Costs and Cost Analysis
  • Cell Separation
  • Blood Platelets
  • Analytical Chemistry
  • Acoustics
  • 09 Engineering
 

Citation

APA
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ICMJE
MLA
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Gu, Y., Chen, C., Wang, Z., Huang, P.-H., Fu, H., Wang, L., … Huang, T. J. (2019). Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation. Lab Chip, 19(3), 394–402. https://doi.org/10.1039/c8lc00527c
Gu, Yuyang, Chuyi Chen, Zeyu Wang, Po-Hsun Huang, Hai Fu, Lin Wang, Mengxi Wu, et al. “Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation.Lab Chip 19, no. 3 (January 29, 2019): 394–402. https://doi.org/10.1039/c8lc00527c.
Gu Y, Chen C, Wang Z, Huang P-H, Fu H, Wang L, et al. Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation. Lab Chip. 2019 Jan 29;19(3):394–402.
Gu, Yuyang, et al. “Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation.Lab Chip, vol. 19, no. 3, Jan. 2019, pp. 394–402. Pubmed, doi:10.1039/c8lc00527c.
Gu Y, Chen C, Wang Z, Huang P-H, Fu H, Wang L, Wu M, Chen Y, Gao T, Gong J, Kwun J, Arepally GM, Huang TJ. Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation. Lab Chip. 2019 Jan 29;19(3):394–402.
Journal cover image

Published In

Lab Chip

DOI

EISSN

1473-0189

Publication Date

January 29, 2019

Volume

19

Issue

3

Start / End Page

394 / 402

Location

England

Related Subject Headings

  • Plastics
  • Humans
  • Equipment Design
  • Disposable Equipment
  • Costs and Cost Analysis
  • Cell Separation
  • Blood Platelets
  • Analytical Chemistry
  • Acoustics
  • 09 Engineering