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Methods for comparing durability of immune responses between vaccine regimens in early-phase trials.

Publication ,  Journal Article
Westling, T; Juraska, M; Seaton, KE; Tomaras, GD; Gilbert, PB; Janes, H
Published in: Stat Methods Med Res
January 2020

The ability to produce a long-lasting, or durable, immune response is a crucial characteristic of many highly effective vaccines. A goal of early-phase vaccine trials is often to compare the immune response durability of multiple tested vaccine regimens. One parameter for measuring immune response durability is the area under the mean post-peak log immune response profile. In this paper, we compare immune response durability across vaccine regimens within and between two phase I trials of DNA-primed HIV vaccine regimens, HVTN 094 and HVTN 096. We compare four estimators of this durability parameter and the resulting statistical inferences for comparing vaccine regimens. Two of these estimators use the trapezoid rule as an empirical approximation of the area under the marginal log response curve, and the other two estimators are based on linear and nonlinear models for the marginal mean log response. We conduct a simulation study to compare the four estimators, provide guidance on estimator selection, and use the nonlinear marginal mean model to analyze immunogenicity data from the two HIV vaccine trials.

Duke Scholars

Published In

Stat Methods Med Res

DOI

EISSN

1477-0334

Publication Date

January 2020

Volume

29

Issue

1

Start / End Page

78 / 93

Location

England

Related Subject Headings

  • Statistics & Probability
  • Research Design
  • Humans
  • HIV Infections
  • Data Interpretation, Statistical
  • Clinical Trials as Topic
  • AIDS Vaccines
  • 4905 Statistics
  • 4202 Epidemiology
  • 1117 Public Health and Health Services
 

Citation

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Westling, T., Juraska, M., Seaton, K. E., Tomaras, G. D., Gilbert, P. B., & Janes, H. (2020). Methods for comparing durability of immune responses between vaccine regimens in early-phase trials. Stat Methods Med Res, 29(1), 78–93. https://doi.org/10.1177/0962280218820881
Westling, Ted, Michal Juraska, Kelly E. Seaton, Georgia D. Tomaras, Peter B. Gilbert, and Holly Janes. “Methods for comparing durability of immune responses between vaccine regimens in early-phase trials.Stat Methods Med Res 29, no. 1 (January 2020): 78–93. https://doi.org/10.1177/0962280218820881.
Westling T, Juraska M, Seaton KE, Tomaras GD, Gilbert PB, Janes H. Methods for comparing durability of immune responses between vaccine regimens in early-phase trials. Stat Methods Med Res. 2020 Jan;29(1):78–93.
Westling, Ted, et al. “Methods for comparing durability of immune responses between vaccine regimens in early-phase trials.Stat Methods Med Res, vol. 29, no. 1, Jan. 2020, pp. 78–93. Pubmed, doi:10.1177/0962280218820881.
Westling T, Juraska M, Seaton KE, Tomaras GD, Gilbert PB, Janes H. Methods for comparing durability of immune responses between vaccine regimens in early-phase trials. Stat Methods Med Res. 2020 Jan;29(1):78–93.
Journal cover image

Published In

Stat Methods Med Res

DOI

EISSN

1477-0334

Publication Date

January 2020

Volume

29

Issue

1

Start / End Page

78 / 93

Location

England

Related Subject Headings

  • Statistics & Probability
  • Research Design
  • Humans
  • HIV Infections
  • Data Interpretation, Statistical
  • Clinical Trials as Topic
  • AIDS Vaccines
  • 4905 Statistics
  • 4202 Epidemiology
  • 1117 Public Health and Health Services