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Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange.

Publication ,  Journal Article
Lindale, JR; Eriksson, SL; Tanner, CPN; Zhou, Z; Colell, JFP; Zhang, G; Bae, J; Chekmenev, EY; Theis, T; Warren, WS
Published in: Nature communications
January 2019

Signal amplification by reversible exchange (SABRE) is an efficient method to hyperpolarize spin-1/2 nuclei and affords signals that are orders of magnitude larger than those obtained by thermal spin polarization. Direct polarization transfer to heteronuclei such as 13C or 15N has been optimized at static microTesla fields or using coherence transfer at high field, and relies on steady state exchange with the polarization transfer catalyst dictated by chemical kinetics. Here we demonstrate that pulsing the excitation field induces complex coherent polarization transfer dynamics, but in fact pulsing with a roughly 1% duty cycle on resonance produces more magnetization than constantly being on resonance. We develop a Monte Carlo simulation approach to unravel the coherent polarization dynamics, show that existing SABRE approaches are quite inefficient in use of para-hydrogen order, and present improved sequences for efficient hyperpolarization.

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Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

January 2019

Volume

10

Issue

1

Start / End Page

395

Related Subject Headings

  • Pyridines
  • Nitrogen Isotopes
  • Models, Theoretical
  • Models, Molecular
  • Magnetic Resonance Spectroscopy
  • Magnetic Fields
  • Kinetics
  • Hydrogen
  • Catalysis
 

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Lindale, J. R., Eriksson, S. L., Tanner, C. P. N., Zhou, Z., Colell, J. F. P., Zhang, G., … Warren, W. S. (2019). Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange. Nature Communications, 10(1), 395. https://doi.org/10.1038/s41467-019-08298-8
Lindale, Jacob R., Shannon L. Eriksson, Christian P. N. Tanner, Zijian Zhou, Johannes F. P. Colell, Guannan Zhang, Junu Bae, Eduard Y. Chekmenev, Thomas Theis, and Warren S. Warren. “Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange.Nature Communications 10, no. 1 (January 2019): 395. https://doi.org/10.1038/s41467-019-08298-8.
Lindale JR, Eriksson SL, Tanner CPN, Zhou Z, Colell JFP, Zhang G, et al. Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange. Nature communications. 2019 Jan;10(1):395.
Lindale, Jacob R., et al. “Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange.Nature Communications, vol. 10, no. 1, Jan. 2019, p. 395. Epmc, doi:10.1038/s41467-019-08298-8.
Lindale JR, Eriksson SL, Tanner CPN, Zhou Z, Colell JFP, Zhang G, Bae J, Chekmenev EY, Theis T, Warren WS. Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange. Nature communications. 2019 Jan;10(1):395.

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

January 2019

Volume

10

Issue

1

Start / End Page

395

Related Subject Headings

  • Pyridines
  • Nitrogen Isotopes
  • Models, Theoretical
  • Models, Molecular
  • Magnetic Resonance Spectroscopy
  • Magnetic Fields
  • Kinetics
  • Hydrogen
  • Catalysis