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A systems-based model of Alzheimer's disease.

Publication ,  Journal Article
Tang, Y; Lutz, MW; Xing, Y
Published in: Alzheimers Dement
January 2019

The new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer's disease conceptual models. However, as a "complex" disease, a model based on systems-level understanding is needed to accommodate the complex, interacting etiologic pathways and the system-level changes associated with Alzheimer's disease pathogenesis and interventions that are currently known and which will be identified in the future. To accomplish this, the evolution of the structure of the research framework itself should be encouraged.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

January 2019

Volume

15

Issue

1

Start / End Page

168 / 171

Location

United States

Related Subject Headings

  • United States
  • Systems Biology
  • National Institute on Aging (U.S.)
  • Humans
  • Geriatrics
  • Alzheimer Disease
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
 

Citation

APA
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ICMJE
MLA
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Tang, Y., Lutz, M. W., & Xing, Y. (2019). A systems-based model of Alzheimer's disease. Alzheimers Dement, 15(1), 168–171. https://doi.org/10.1016/j.jalz.2018.06.3058
Tang, Yi, Michael W. Lutz, and Yi Xing. “A systems-based model of Alzheimer's disease.Alzheimers Dement 15, no. 1 (January 2019): 168–71. https://doi.org/10.1016/j.jalz.2018.06.3058.
Tang Y, Lutz MW, Xing Y. A systems-based model of Alzheimer's disease. Alzheimers Dement. 2019 Jan;15(1):168–71.
Tang, Yi, et al. “A systems-based model of Alzheimer's disease.Alzheimers Dement, vol. 15, no. 1, Jan. 2019, pp. 168–71. Pubmed, doi:10.1016/j.jalz.2018.06.3058.
Tang Y, Lutz MW, Xing Y. A systems-based model of Alzheimer's disease. Alzheimers Dement. 2019 Jan;15(1):168–171.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

January 2019

Volume

15

Issue

1

Start / End Page

168 / 171

Location

United States

Related Subject Headings

  • United States
  • Systems Biology
  • National Institute on Aging (U.S.)
  • Humans
  • Geriatrics
  • Alzheimer Disease
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences