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Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial.

Publication ,  Journal Article
Lang, JE; Mougey, EB; Hossain, MJ; Livingston, F; Balagopal, PB; Langdon, S; Lima, JJ
Published in: Ann Am Thorac Soc
May 2019

Rationale: Omega-3 fatty acid (n3PUFA) supplementation has been proposed as a promising antiasthma strategy. The rs59439148 ALOX5 polymorphism affects leukotriene production and possibly inflammatory responses to n3PUFA. Objectives: Assess the effects of n3PUFA supplementation and ALOX5 genotype on asthma control in patients with obesity and uncontrolled asthma. Methods: This multicenter trial among 12- to 25-year-olds with overweight/obesity and uncontrolled asthma randomized subjects in a 3:1 allotment to n3PUFA (4 g/d) or soy oil control for 24 weeks. Asthma Control Questionnaire was the primary outcome; secondary outcomes included blood leukocyte n3PUFA levels, urinary leukotriene-E4, spirometry, and asthma-related events. The number of SP1 tandem repeats in rs59439148 determined ALOX5 genotype status. Simple and multivariable generalized linear models assessed effects on outcomes. Results: Ninety-eight participants were randomized (77 to PUFA, 21 to control), and more than 86% completed all visits. Asthma and demographic characteristics were similar among treatment groups. n3PUFA treatment increased the n3-to-n6 PUFA ratio in circulating granulocytes (P = 0.029) and monocytes (P = 0.004) but did not affect mean Asthma Control Questionnaire change at 6 months (n3PUFA: mean, -0.09; 95% confidence interval [CI], 0.09 to 0.10; vs. control: mean, -0.18; 95% CI, -0.42 to 0.06; P = 0.58). Changes in urinary leukotriene-E4 (P = 0.24), forced expiratory volume in 1 second % predicted (P = 0.88), and exacerbations (relative risk [RR], 0.92; 95% CI, 0.30-2.89) at 6 months were similar in both groups. n3PUFA treatment was associated with reduced asthma-related phone contacts (RR, 0.34; 95% CI, 0.13-0.86; P = 0.02). ALOX5 genotype did not affect n3PUFA treatment responses. Conclusions: We did not find evidence that n3PUFA use improves most asthma-related outcomes and cannot recommend it as a prevention strategy for overweight/obese patients with asthma. Clinical trial registered with www.clinicaltrials.gov (NCT01027143).

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Published In

Ann Am Thorac Soc

DOI

EISSN

2325-6621

Publication Date

May 2019

Volume

16

Issue

5

Start / End Page

554 / 562

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Overweight
  • Obesity
  • Male
  • Humans
  • Forced Expiratory Volume
  • Follow-Up Studies
  • Fish Oils
  • Female
 

Citation

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Lang, J. E., Mougey, E. B., Hossain, M. J., Livingston, F., Balagopal, P. B., Langdon, S., & Lima, J. J. (2019). Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial. Ann Am Thorac Soc, 16(5), 554–562. https://doi.org/10.1513/AnnalsATS.201807-446OC
Lang, Jason E., Edward B. Mougey, Md Jobayer Hossain, Floyd Livingston, P Babu Balagopal, Scott Langdon, and John J. Lima. “Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial.Ann Am Thorac Soc 16, no. 5 (May 2019): 554–62. https://doi.org/10.1513/AnnalsATS.201807-446OC.
Lang JE, Mougey EB, Hossain MJ, Livingston F, Balagopal PB, Langdon S, et al. Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial. Ann Am Thorac Soc. 2019 May;16(5):554–62.
Lang, Jason E., et al. “Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial.Ann Am Thorac Soc, vol. 16, no. 5, May 2019, pp. 554–62. Pubmed, doi:10.1513/AnnalsATS.201807-446OC.
Lang JE, Mougey EB, Hossain MJ, Livingston F, Balagopal PB, Langdon S, Lima JJ. Fish Oil Supplementation in Overweight/Obese Patients with Uncontrolled Asthma. A Randomized Trial. Ann Am Thorac Soc. 2019 May;16(5):554–562.

Published In

Ann Am Thorac Soc

DOI

EISSN

2325-6621

Publication Date

May 2019

Volume

16

Issue

5

Start / End Page

554 / 562

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Overweight
  • Obesity
  • Male
  • Humans
  • Forced Expiratory Volume
  • Follow-Up Studies
  • Fish Oils
  • Female