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Metabolic syndrome and risk of breast cancer mortality by menopause, obesity, and subtype.

Publication ,  Journal Article
Dibaba, DT; Ogunsina, K; Braithwaite, D; Akinyemiju, T
Published in: Breast Cancer Res Treat
February 2019

PURPOSE: To investigate the association between metabolic syndrome (MetS) and risk of breast cancer mortality by menopausal status, obesity, and subtype. METHODS: Data from 94,555 women free of cancer at baseline in the National Institute of Health-American Association of Retired Persons Diet and Health Study cohort (NIH-AARP) were used to investigate the prospective associations of baseline MetS and components with risk of breast cancer mortality using Cox proportional hazard regression models adjusted for baseline behavioral and demographic covariates. RESULTS: During a mean follow-up duration of 14 years, 607 women in the cohort died of breast cancer. Overall, MetS was associated with a 73% increased risk of breast cancer mortality (HR 1.73; 95% CI 1.09-2.75); the association remained significant among post-menopausal women overall (HR 2.07, 95% CI 1.32, 3.25), and among those with overweight/obesity (HR 1.15, 95% CI 0.81, 1.64). MetS was associated with increased risk of breast cancer mortality for ER+/PR+ (HR 1.28, 95% CI 0.52, 3.16) and lower risk for ER-/PR- (HR 0.44, 95% CI 0.11, 1.75) subtypes; however, the associations were not statistically significant. Of the individual MetS components, high waist circumference (HR 1.32, 95% CI 1.03, 1.70), high cholesterol (HR 1.24, 95% CI 1.05, 1.46), and hypertension (HR 1.24, 95% CI 1.05, 1.46) were independently associated with increased risk of breast cancer mortality. CONCLUSIONS: MetS was associated with increased risk of breast cancer mortality, especially among post-menopausal women. Further studies with larger sample sizes are needed to definitively determine the extent to which these associations vary by breast cancer subtype.

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Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

February 2019

Volume

174

Issue

1

Start / End Page

209 / 218

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Oncology & Carcinogenesis
  • Obesity
  • Middle Aged
  • Metabolic Syndrome
  • Menopause
  • Humans
  • Female
  • Breast Neoplasms
  • Aged
 

Citation

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Dibaba, D. T., Ogunsina, K., Braithwaite, D., & Akinyemiju, T. (2019). Metabolic syndrome and risk of breast cancer mortality by menopause, obesity, and subtype. Breast Cancer Res Treat, 174(1), 209–218. https://doi.org/10.1007/s10549-018-5056-8
Dibaba, Daniel T., Kemi Ogunsina, Dejana Braithwaite, and Tomi Akinyemiju. “Metabolic syndrome and risk of breast cancer mortality by menopause, obesity, and subtype.Breast Cancer Res Treat 174, no. 1 (February 2019): 209–18. https://doi.org/10.1007/s10549-018-5056-8.
Dibaba DT, Ogunsina K, Braithwaite D, Akinyemiju T. Metabolic syndrome and risk of breast cancer mortality by menopause, obesity, and subtype. Breast Cancer Res Treat. 2019 Feb;174(1):209–18.
Dibaba, Daniel T., et al. “Metabolic syndrome and risk of breast cancer mortality by menopause, obesity, and subtype.Breast Cancer Res Treat, vol. 174, no. 1, Feb. 2019, pp. 209–18. Pubmed, doi:10.1007/s10549-018-5056-8.
Dibaba DT, Ogunsina K, Braithwaite D, Akinyemiju T. Metabolic syndrome and risk of breast cancer mortality by menopause, obesity, and subtype. Breast Cancer Res Treat. 2019 Feb;174(1):209–218.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

February 2019

Volume

174

Issue

1

Start / End Page

209 / 218

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Oncology & Carcinogenesis
  • Obesity
  • Middle Aged
  • Metabolic Syndrome
  • Menopause
  • Humans
  • Female
  • Breast Neoplasms
  • Aged