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Racial/ethnic disparities in de novo metastases sites and survival outcomes for patients with primary breast, colorectal, and prostate cancer.

Publication ,  Journal Article
Akinyemiju, T; Sakhuja, S; Waterbor, J; Pisu, M; Altekruse, SF
Published in: Cancer Med
April 2018

Racial disparities in cancer mortality still exist despite improvements in treatment strategies leading to improved survival for many cancer types. In this study, we described race/ethnic differences in patterns of de novo metastasis and evaluated the association between site of de novo metastasis and breast, prostate, and colorectal cancer mortality. Data were obtained from the Surveillance Epidemiology and Ends Results (SEER) database from 2010 to 2013 and included 520,147 patients ages ≥40 years with primary diagnosis of breast, colorectal, or prostate cancer. Site and frequency of de novo metastases to four sites (bone, brain, liver, and lung) were compared by race/ethnicity using descriptive statistics, and survival differences examined using extended Cox regression models in SAS 9.4. Overall, non-Hispanic (NH) Blacks (11%) were more likely to present with de novo metastasis compared with NH-Whites (9%) or Hispanics (10%). Among patients with breast cancer, NH-Blacks were more likely to have metastasis to the bone, (OR: 1.25, 95% CI: 1.15-1.37), brain (OR: 2.26, 95% CI: 1.57-3.25), or liver (OR: 1.62, 95% CI: 1.35-1.93), while Hispanics were less likely to have metastasis to the liver (OR: 0.76, 95% CI: 0.60-0.97) compared with NH-Whites. Among patients with prostate cancer, NH-Blacks (1.39, 95% CI: 1.31-1.48) and Hispanics (1.39, 95% CI: 1.29-1.49) were more likely to have metastasis to the bone. Metastasis to any of the four sites evaluated increased overall mortality by threefold (for breast cancer and metastasis to bone) to 17-fold (for prostate cancer and metastasis to liver). Racial disparities in mortality remained after adjusting for metastasis site in all cancer types evaluated. De novo metastasis is a major contributor to cancer mortality in USA with racial differences in the site, frequency, and associated survival.

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Published In

Cancer Med

DOI

EISSN

2045-7634

Publication Date

April 2018

Volume

7

Issue

4

Start / End Page

1183 / 1193

Location

United States

Related Subject Headings

  • United States
  • Survival Rate
  • Socioeconomic Factors
  • SEER Program
  • Prostatic Neoplasms
  • Proportional Hazards Models
  • Population Surveillance
  • Odds Ratio
  • Neoplasm Staging
  • Neoplasm Metastasis
 

Citation

APA
Chicago
ICMJE
MLA
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Akinyemiju, T., Sakhuja, S., Waterbor, J., Pisu, M., & Altekruse, S. F. (2018). Racial/ethnic disparities in de novo metastases sites and survival outcomes for patients with primary breast, colorectal, and prostate cancer. Cancer Med, 7(4), 1183–1193. https://doi.org/10.1002/cam4.1322
Akinyemiju, Tomi, Swati Sakhuja, John Waterbor, Maria Pisu, and Sean F. Altekruse. “Racial/ethnic disparities in de novo metastases sites and survival outcomes for patients with primary breast, colorectal, and prostate cancer.Cancer Med 7, no. 4 (April 2018): 1183–93. https://doi.org/10.1002/cam4.1322.
Akinyemiju T, Sakhuja S, Waterbor J, Pisu M, Altekruse SF. Racial/ethnic disparities in de novo metastases sites and survival outcomes for patients with primary breast, colorectal, and prostate cancer. Cancer Med. 2018 Apr;7(4):1183–93.
Akinyemiju, Tomi, et al. “Racial/ethnic disparities in de novo metastases sites and survival outcomes for patients with primary breast, colorectal, and prostate cancer.Cancer Med, vol. 7, no. 4, Apr. 2018, pp. 1183–93. Pubmed, doi:10.1002/cam4.1322.
Akinyemiju T, Sakhuja S, Waterbor J, Pisu M, Altekruse SF. Racial/ethnic disparities in de novo metastases sites and survival outcomes for patients with primary breast, colorectal, and prostate cancer. Cancer Med. 2018 Apr;7(4):1183–1193.
Journal cover image

Published In

Cancer Med

DOI

EISSN

2045-7634

Publication Date

April 2018

Volume

7

Issue

4

Start / End Page

1183 / 1193

Location

United States

Related Subject Headings

  • United States
  • Survival Rate
  • Socioeconomic Factors
  • SEER Program
  • Prostatic Neoplasms
  • Proportional Hazards Models
  • Population Surveillance
  • Odds Ratio
  • Neoplasm Staging
  • Neoplasm Metastasis