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A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort.

Publication ,  Journal Article
Moore, JX; Akinyemiju, T; Bartolucci, A; Wang, HE; Waterbor, J; Griffin, R
Published in: Cancer Epidemiol
August 2018

BACKGROUND: Hospitalized cancer patients are nearly 10 times more likely to develop sepsis when compared to patients with no cancer history. We compared the risk of sepsis between cancer survivors and no cancer history participants, and examined whether race was an effect modifier. METHODS: We performed a prospective analysis of data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We categorized participants as "cancer survivors" or "no cancer history" derived from self-reported responses of being diagnosed with any cancer, excluding non-melanoma skin cancer. We defined sepsis as hospitalization for a serious infection with ≥2 systemic inflammatory response syndrome criteria. We performed Cox proportional hazard models to examine the risk of sepsis after cancer (adjusted for sociodemographics, health behaviors, and comorbidities), and stratified by race. RESULTS: Among 29,693 eligible participants, 2959 (9.97%) were cancer survivors, and 26,734 (90.03%) were no cancer history participants. Among 1393 sepsis events, the risk of sepsis was higher for cancer survivors (adjusted HR: 2.61, 95% CI: 2.29-2.98) when compared to no cancer history participants. Risk of sepsis after cancer survivorship was similar for Black and White participants (p value for race and cancer interaction = 0.63). CONCLUSION: In this prospective cohort of community-dwelling adults we observed that cancer survivors had more than a 2.5-fold increased risk of sepsis. Public health efforts should attempt to mitigate sepsis risk by awareness and appropriate treatment (e.g., antibiotic administration) to cancer survivors with suspected infection regardless of the number of years since cancer remission.

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Published In

Cancer Epidemiol

DOI

EISSN

1877-783X

Publication Date

August 2018

Volume

55

Start / End Page

30 / 38

Location

Netherlands

Related Subject Headings

  • White People
  • Sepsis
  • Risk Factors
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Hospitalization
  • Health Behavior
 

Citation

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Moore, J. X., Akinyemiju, T., Bartolucci, A., Wang, H. E., Waterbor, J., & Griffin, R. (2018). A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort. Cancer Epidemiol, 55, 30–38. https://doi.org/10.1016/j.canep.2018.05.001
Moore, Justin Xavier, Tomi Akinyemiju, Alfred Bartolucci, Henry E. Wang, John Waterbor, and Russell Griffin. “A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort.Cancer Epidemiol 55 (August 2018): 30–38. https://doi.org/10.1016/j.canep.2018.05.001.
Moore JX, Akinyemiju T, Bartolucci A, Wang HE, Waterbor J, Griffin R. A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort. Cancer Epidemiol. 2018 Aug;55:30–8.
Moore, Justin Xavier, et al. “A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort.Cancer Epidemiol, vol. 55, Aug. 2018, pp. 30–38. Pubmed, doi:10.1016/j.canep.2018.05.001.
Moore JX, Akinyemiju T, Bartolucci A, Wang HE, Waterbor J, Griffin R. A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort. Cancer Epidemiol. 2018 Aug;55:30–38.
Journal cover image

Published In

Cancer Epidemiol

DOI

EISSN

1877-783X

Publication Date

August 2018

Volume

55

Start / End Page

30 / 38

Location

Netherlands

Related Subject Headings

  • White People
  • Sepsis
  • Risk Factors
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Hospitalization
  • Health Behavior