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Clinical studies of hemodialysis access through formaldehyde-fixed arterial allografts.

Publication ,  Journal Article
Liu, Z; Zhu, B; Wang, X; Jing, Y; Wang, P; Wang, S; Xu, H
Published in: Kidney Int
November 2007

Efficient hemodialysis requires establishing a permanent stable vascular access. Our study was designed to evaluate formaldehyde-fixed arterial allografts as hemodialysis access for end-stage renal disease. Various parameters were determined for 68 formaldehyde-fixed, cadaver-derived allografts transplanted into 43 hemodialysis patients. The sources of the allografts were determined to be free of cytomegalovirus, hepatitis B and hepatitis C, and HIV infections. These allografts were monitored for rejection, blood flow, patency rates, and complications. Overall, antigenicity of the allografts was reduced after formaldehyde fixation with no acute rejection. The mean access blood flow was 696+/-282 ml with reasonable primary and secondary patency rates even after 3 years. Allograft intimal hyperplasia, determined by immunohistochemistry, was evident as the proliferation of smooth muscle-like cells expressing actin but cells not expressing the endothelial markers von Willebrand factor or CD34. The incidence of thrombus formation was about 37% after allograft transplant with other limited complications of pseudoaneurysms and local infection. Our results support the clinical use of formaldehyde-fixed arterial allografts for hemodialysis access.

Duke Scholars

Published In

Kidney Int

DOI

ISSN

0085-2538

Publication Date

November 2007

Volume

72

Issue

10

Start / End Page

1249 / 1254

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Ultrasonography
  • Transplantation, Homologous
  • Renal Dialysis
  • Prospective Studies
  • Middle Aged
  • Male
  • Kidney Failure, Chronic
  • Immunohistochemistry
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, Z., Zhu, B., Wang, X., Jing, Y., Wang, P., Wang, S., & Xu, H. (2007). Clinical studies of hemodialysis access through formaldehyde-fixed arterial allografts. Kidney Int, 72(10), 1249–1254. https://doi.org/10.1038/sj.ki.5002474
Liu, Z., B. Zhu, X. Wang, Y. Jing, P. Wang, S. Wang, and H. Xu. “Clinical studies of hemodialysis access through formaldehyde-fixed arterial allografts.Kidney Int 72, no. 10 (November 2007): 1249–54. https://doi.org/10.1038/sj.ki.5002474.
Liu Z, Zhu B, Wang X, Jing Y, Wang P, Wang S, et al. Clinical studies of hemodialysis access through formaldehyde-fixed arterial allografts. Kidney Int. 2007 Nov;72(10):1249–54.
Liu, Z., et al. “Clinical studies of hemodialysis access through formaldehyde-fixed arterial allografts.Kidney Int, vol. 72, no. 10, Nov. 2007, pp. 1249–54. Pubmed, doi:10.1038/sj.ki.5002474.
Liu Z, Zhu B, Wang X, Jing Y, Wang P, Wang S, Xu H. Clinical studies of hemodialysis access through formaldehyde-fixed arterial allografts. Kidney Int. 2007 Nov;72(10):1249–1254.
Journal cover image

Published In

Kidney Int

DOI

ISSN

0085-2538

Publication Date

November 2007

Volume

72

Issue

10

Start / End Page

1249 / 1254

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Ultrasonography
  • Transplantation, Homologous
  • Renal Dialysis
  • Prospective Studies
  • Middle Aged
  • Male
  • Kidney Failure, Chronic
  • Immunohistochemistry
  • Humans