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Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study.

Publication ,  Journal Article
Edwards, JM; Watson, N; Focht, C; Wynn, C; Todd, CA; Walter, EB; Heine, RP; Swamy, GK
Published in: Infect Dis Obstet Gynecol
2019

BACKGROUND: Maternal GBS colonization is associated with early-onset neonatal sepsis and extensive efforts are directed to preventing this complication. Less is known about maternal risks of GBS colonization. We seek to provide a modern estimate of the incidence and impact of maternal GBS colonization and invasive GBS disease. METHODS: A single center historical cohort study of all births between 2003 and 2015 was performed. Data was collected via electronic health record abstraction using an institutional specific tool. Descriptive statistics were performed regarding GBS status. Inferential statistics were performed comparing risk of adverse pregnancy outcomes in cohorts with and without GBS colonization as well as cohorts with GBS colonization and invasive GBS disease. RESULTS: A total of 60,029 deliveries were included for analysis. Overall, 21.6% of the population was GBS colonized and 0.1% had invasive GBS disease. GBS colonization was associated with younger maternal age, Black race, non-Hispanic ethnicity, chronic hypertension, preexisting diabetes, and tobacco use (p<0.01). In the adjusted analyses, there was an increased risk of gestational diabetes (aRR 1.21, 95% CI 1.11-1.32) in colonized pregnancies and a decreased incidence of short cervix (aRR 0.64, 95% CI 0.52-0.79), chorioamnionitis (aRR 0.76, 95% CI 0.66-0.87), wound infection (aRR 0.75, 95% CI 0.64-0.88), and operative delivery (aRR 0.85, 95% CI 0.83-0.88). CONCLUSIONS: This modern-day large cohort of all births over a 12-year period demonstrates a GBS colonization rate of 21.6%. This data reflects a need to assess maternal and perinatal outcomes in addition to neonatal GBS sepsis rates to inform decisions regarding the utility of maternal vaccination.

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Published In

Infect Dis Obstet Gynecol

DOI

EISSN

1098-0997

Publication Date

2019

Volume

2019

Start / End Page

5430493

Location

Egypt

Related Subject Headings

  • United States
  • Streptococcus agalactiae
  • Streptococcal Infections
  • Risk Factors
  • Prevalence
  • Pregnancy Outcome
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Humans
 

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ICMJE
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Edwards, J. M., Watson, N., Focht, C., Wynn, C., Todd, C. A., Walter, E. B., … Swamy, G. K. (2019). Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study. Infect Dis Obstet Gynecol, 2019, 5430493. https://doi.org/10.1155/2019/5430493
Edwards, James M., Nora Watson, Chris Focht, Clara Wynn, Christopher A. Todd, Emmanuel B. Walter, R Phillips Heine, and Geeta K. Swamy. “Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study.Infect Dis Obstet Gynecol 2019 (2019): 5430493. https://doi.org/10.1155/2019/5430493.
Edwards JM, Watson N, Focht C, Wynn C, Todd CA, Walter EB, et al. Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study. Infect Dis Obstet Gynecol. 2019;2019:5430493.
Edwards, James M., et al. “Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study.Infect Dis Obstet Gynecol, vol. 2019, 2019, p. 5430493. Pubmed, doi:10.1155/2019/5430493.
Edwards JM, Watson N, Focht C, Wynn C, Todd CA, Walter EB, Heine RP, Swamy GK. Group B Streptococcus (GBS) Colonization and Disease among Pregnant Women: A Historical Cohort Study. Infect Dis Obstet Gynecol. 2019;2019:5430493.
Journal cover image

Published In

Infect Dis Obstet Gynecol

DOI

EISSN

1098-0997

Publication Date

2019

Volume

2019

Start / End Page

5430493

Location

Egypt

Related Subject Headings

  • United States
  • Streptococcus agalactiae
  • Streptococcal Infections
  • Risk Factors
  • Prevalence
  • Pregnancy Outcome
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Humans