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Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.

Publication ,  Journal Article
McKey, J; Bunce, C; Batchvarov, IS; Ornitz, DM; Capel, B
Published in: Proc Natl Acad Sci U S A
March 19, 2019

Testes and ovaries undergo sex-specific morphogenetic changes and adopt strikingly different morphologies, despite the fact that both arise from a common precursor, the bipotential gonad. Previous studies showed that recruitment of vasculature is critical for testis patterning. However, vasculature is not recruited into the early ovary. Peripheral innervation is involved in patterning development of many organs but has been given little attention in gonad development. In this study, we show that while innervation in the male reproductive complex is restricted to the epididymis and vas deferens and never invades the interior of the testis, neural crest-derived innervation invades the interior of the ovary around E16.5. Individual neural crest cells colonize the ovary, differentiate into neurons and glia, and form a dense neural network within the ovarian medulla. Using a sex-reversing mutant mouse line, we show that innervation is specific to ovary development, is not dependent on the genetic sex of gonadal or neural crest cells, and may be blocked by repressive guidance signals elevated in the male pathway. This study reveals another aspect of sexually dimorphic gonad development, establishes a precise timeline and structure of ovarian innervation, and raises many questions for future research.

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Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

March 19, 2019

Volume

116

Issue

12

Start / End Page

5570 / 5575

Location

United States

Related Subject Headings

  • Testis
  • Sex Differentiation
  • Sex Determination Processes
  • Sex Characteristics
  • Ovary
  • Neurons
  • Neural Crest
  • Morphogenesis
  • Mice, Inbred C57BL
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
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McKey, J., Bunce, C., Batchvarov, I. S., Ornitz, D. M., & Capel, B. (2019). Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development. Proc Natl Acad Sci U S A, 116(12), 5570–5575. https://doi.org/10.1073/pnas.1814930116
McKey, Jennifer, Corey Bunce, Iordan S. Batchvarov, David M. Ornitz, and Blanche Capel. “Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.Proc Natl Acad Sci U S A 116, no. 12 (March 19, 2019): 5570–75. https://doi.org/10.1073/pnas.1814930116.
McKey J, Bunce C, Batchvarov IS, Ornitz DM, Capel B. Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5570–5.
McKey, Jennifer, et al. “Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.Proc Natl Acad Sci U S A, vol. 116, no. 12, Mar. 2019, pp. 5570–75. Pubmed, doi:10.1073/pnas.1814930116.
McKey J, Bunce C, Batchvarov IS, Ornitz DM, Capel B. Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5570–5575.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

March 19, 2019

Volume

116

Issue

12

Start / End Page

5570 / 5575

Location

United States

Related Subject Headings

  • Testis
  • Sex Differentiation
  • Sex Determination Processes
  • Sex Characteristics
  • Ovary
  • Neurons
  • Neural Crest
  • Morphogenesis
  • Mice, Inbred C57BL
  • Mice