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Estimation of Gestational Age via Image Analysis of Anterior Lens Capsule Vascularity in Preterm Infants: A Pilot Study.

Publication ,  Journal Article
Patel, M; Mukherjee, D; Farsiu, S; Munoz, B; Blood, AB; Wilson, CG; Griffin, JB
Published in: Frontiers in pediatrics
January 2019

Introduction: Anterior lens capsule vascularity (ALCV) is resorbed in the developing fetus from 27 to 35 weeks gestation. In this pilot study, we evaluated the feasibility and validity of combining smartphone ophthalmoscope videos of ALCV and image analysis for gestational age estimation. Methods: ALCV videos were captured longitudinally in preterm neonates from delivery using a PanOptic® Ophthalmoscope with an iExaminer® adapter (Welch-Allyn). ALCV video frames were manually selected and quantified using semi-automatic image analysis. A predictive model based on ALCV features was compared to gold-standard ultrasound gestational age estimates. Results: A total of 64 image-capture sessions were carried out in 24 neonates. Ultrasound-estimated gestational age and ALCV-predicted gestational age estimates indicate that the two methods are similar (r = 0.78, p < 0.0001). ALCV estimates of gestational age were within 0.11 ± 1.3 weeks of ultrasound estimates. In the final model, gestational age was predicted within ± 1 week for 54% and within ± 2 weeks for 86% of the measures. Conclusions: This novel application of smartphone ophthalmoscopy and ALCV image analysis may provide a safe, accurate and non-invasive technology to estimate postnatal gestational age, especially in low income countries where gestational age may not be known at birth.

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Published In

Frontiers in pediatrics

DOI

EISSN

2296-2360

ISSN

2296-2360

Publication Date

January 2019

Volume

7

Start / End Page

43

Related Subject Headings

  • 3213 Paediatrics
  • 1199 Other Medical and Health Sciences
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

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MLA
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Patel, M., Mukherjee, D., Farsiu, S., Munoz, B., Blood, A. B., Wilson, C. G., & Griffin, J. B. (2019). Estimation of Gestational Age via Image Analysis of Anterior Lens Capsule Vascularity in Preterm Infants: A Pilot Study. Frontiers in Pediatrics, 7, 43. https://doi.org/10.3389/fped.2019.00043
Patel, Monalisa, Dibyendu Mukherjee, Sina Farsiu, Breda Munoz, Arlin B. Blood, Christopher G. Wilson, and Jennifer B. Griffin. “Estimation of Gestational Age via Image Analysis of Anterior Lens Capsule Vascularity in Preterm Infants: A Pilot Study.Frontiers in Pediatrics 7 (January 2019): 43. https://doi.org/10.3389/fped.2019.00043.
Patel M, Mukherjee D, Farsiu S, Munoz B, Blood AB, Wilson CG, et al. Estimation of Gestational Age via Image Analysis of Anterior Lens Capsule Vascularity in Preterm Infants: A Pilot Study. Frontiers in pediatrics. 2019 Jan;7:43.
Patel, Monalisa, et al. “Estimation of Gestational Age via Image Analysis of Anterior Lens Capsule Vascularity in Preterm Infants: A Pilot Study.Frontiers in Pediatrics, vol. 7, Jan. 2019, p. 43. Epmc, doi:10.3389/fped.2019.00043.
Patel M, Mukherjee D, Farsiu S, Munoz B, Blood AB, Wilson CG, Griffin JB. Estimation of Gestational Age via Image Analysis of Anterior Lens Capsule Vascularity in Preterm Infants: A Pilot Study. Frontiers in pediatrics. 2019 Jan;7:43.

Published In

Frontiers in pediatrics

DOI

EISSN

2296-2360

ISSN

2296-2360

Publication Date

January 2019

Volume

7

Start / End Page

43

Related Subject Headings

  • 3213 Paediatrics
  • 1199 Other Medical and Health Sciences
  • 1114 Paediatrics and Reproductive Medicine