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Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies.

Publication ,  Journal Article
Kochanek, PM; Tasker, RC; Bell, MJ; Adelson, PD; Carney, N; Vavilala, MS; Selden, NR; Bratton, SL; Grant, GA; Kissoon, N; Reuter-Rice, KE ...
Published in: Pediatr Crit Care Med
March 2019

OBJECTIVES: To produce a treatment algorithm for the ICU management of infants, children, and adolescents with severe traumatic brain injury. DATA SOURCES: Studies included in the 2019 Guidelines for the Management of Pediatric Severe Traumatic Brain Injury (Glasgow Coma Scale score ≤ 8), consensus when evidence was insufficient to formulate a fully evidence-based approach, and selected protocols from included studies. DATA SYNTHESIS: Baseline care germane to all pediatric patients with severe traumatic brain injury along with two tiers of therapy were formulated. An approach to emergent management of the crisis scenario of cerebral herniation was also included. The first tier of therapy focuses on three therapeutic targets, namely preventing and/or treating intracranial hypertension, optimizing cerebral perfusion pressure, and optimizing partial pressure of brain tissue oxygen (when monitored). The second tier of therapy focuses on decompressive craniectomy surgery, barbiturate infusion, late application of hypothermia, induced hyperventilation, and hyperosmolar therapies. CONCLUSIONS: This article provides an algorithm of clinical practice for the bedside practitioner based on the available evidence, treatment protocols described in the articles included in the 2019 guidelines, and consensus that reflects a logical approach to mitigate intracranial hypertension, optimize cerebral perfusion, and improve outcomes in the setting of pediatric severe traumatic brain injury.

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Published In

Pediatr Crit Care Med

DOI

ISSN

1529-7535

Publication Date

March 2019

Volume

20

Issue

3

Start / End Page

269 / 279

Location

United States

Related Subject Headings

  • Respiration, Artificial
  • Practice Guidelines as Topic
  • Pediatrics
  • Intracranial Hypertension
  • Infant
  • Hypothermia, Induced
  • Humans
  • Glasgow Coma Scale
  • Decompressive Craniectomy
  • Consensus
 

Citation

APA
Chicago
ICMJE
MLA
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Kochanek, P. M., Tasker, R. C., Bell, M. J., Adelson, P. D., Carney, N., Vavilala, M. S., … Wainwright, M. S. (2019). Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies. Pediatr Crit Care Med, 20(3), 269–279. https://doi.org/10.1097/PCC.0000000000001737
Kochanek, Patrick M., Robert C. Tasker, Michael J. Bell, P David Adelson, Nancy Carney, Monica S. Vavilala, Nathan R. Selden, et al. “Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies.Pediatr Crit Care Med 20, no. 3 (March 2019): 269–79. https://doi.org/10.1097/PCC.0000000000001737.
Kochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS, et al. Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies. Pediatr Crit Care Med. 2019 Mar;20(3):269–79.
Kochanek, Patrick M., et al. “Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies.Pediatr Crit Care Med, vol. 20, no. 3, Mar. 2019, pp. 269–79. Pubmed, doi:10.1097/PCC.0000000000001737.
Kochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS, Selden NR, Bratton SL, Grant GA, Kissoon N, Reuter-Rice KE, Wainwright MS. Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies. Pediatr Crit Care Med. 2019 Mar;20(3):269–279.

Published In

Pediatr Crit Care Med

DOI

ISSN

1529-7535

Publication Date

March 2019

Volume

20

Issue

3

Start / End Page

269 / 279

Location

United States

Related Subject Headings

  • Respiration, Artificial
  • Practice Guidelines as Topic
  • Pediatrics
  • Intracranial Hypertension
  • Infant
  • Hypothermia, Induced
  • Humans
  • Glasgow Coma Scale
  • Decompressive Craniectomy
  • Consensus