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Health-related quality of life in glomerular disease.

Publication ,  Journal Article
Canetta, PA; Troost, JP; Mahoney, S; Kogon, AJ; Carlozzi, N; Bartosh, SM; Cai, Y; Davis, TK; Fernandez, H; Fornoni, A; Gbadegesin, RA ...
Published in: Kidney Int
May 2019

There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32% of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95% CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

May 2019

Volume

95

Issue

5

Start / End Page

1209 / 1224

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Self Report
  • Quality of Life
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Glomerulonephritis
  • Female
  • Edema
 

Citation

APA
Chicago
ICMJE
MLA
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Canetta, P. A., Troost, J. P., Mahoney, S., Kogon, A. J., Carlozzi, N., Bartosh, S. M., … CureGN Consortium. (2019). Health-related quality of life in glomerular disease. Kidney Int, 95(5), 1209–1224. https://doi.org/10.1016/j.kint.2018.12.018
Canetta, Pietro A., Jonathan P. Troost, Shannon Mahoney, Amy J. Kogon, Noelle Carlozzi, Sharon M. Bartosh, Yi Cai, et al. “Health-related quality of life in glomerular disease.Kidney Int 95, no. 5 (May 2019): 1209–24. https://doi.org/10.1016/j.kint.2018.12.018.
Canetta PA, Troost JP, Mahoney S, Kogon AJ, Carlozzi N, Bartosh SM, et al. Health-related quality of life in glomerular disease. Kidney Int. 2019 May;95(5):1209–24.
Canetta, Pietro A., et al. “Health-related quality of life in glomerular disease.Kidney Int, vol. 95, no. 5, May 2019, pp. 1209–24. Pubmed, doi:10.1016/j.kint.2018.12.018.
Canetta PA, Troost JP, Mahoney S, Kogon AJ, Carlozzi N, Bartosh SM, Cai Y, Davis TK, Fernandez H, Fornoni A, Gbadegesin RA, Herreshoff E, Mahan JD, Nachman PH, Selewski DT, Sethna CB, Srivastava T, Tuttle KR, Wang C-S, Falk RJ, Gharavi AG, Gillespie BW, Greenbaum LA, Holzman LB, Kretzler M, Robinson BM, Smoyer WE, Guay-Woodford LM, Reeve B, Gipson DS, CureGN Consortium. Health-related quality of life in glomerular disease. Kidney Int. 2019 May;95(5):1209–1224.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

May 2019

Volume

95

Issue

5

Start / End Page

1209 / 1224

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Self Report
  • Quality of Life
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Glomerulonephritis
  • Female
  • Edema