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Genetics and the geography of health, behaviour and attainment.

Publication ,  Journal Article
Belsky, DW; Caspi, A; Arseneault, L; Corcoran, DL; Domingue, BW; Harris, KM; Houts, RM; Mill, JS; Moffitt, TE; Prinz, J; Sugden, K; Wertz, J ...
Published in: Nature human behaviour
June 2019

Young people's life chances can be predicted by characteristics of their neighbourhood1. Children growing up in disadvantaged neighbourhoods exhibit worse physical and mental health and suffer poorer educational and economic outcomes than children growing up in advantaged neighbourhoods. Increasing recognition that aspects of social inequalities tend, in fact, to be geographical inequalities2-5 is stimulating research and focusing policy interest on the role of place in shaping health, behaviour and social outcomes. Where neighbourhood effects are causal, neighbourhood-level interventions can be effective. Where neighbourhood effects reflect selection of families with different characteristics into different neighbourhoods, interventions should instead target families or individuals directly. To test how selection may affect different neighbourhood-linked problems, we linked neighbourhood data with genetic, health and social outcome data for >7,000 European-descent UK and US young people in the E-Risk and Add Health studies. We tested selection/concentration of genetic risks for obesity, schizophrenia, teen pregnancy and poor educational outcomes in high-risk neighbourhoods, including genetic analysis of neighbourhood mobility. Findings argue against genetic selection/concentration as an explanation for neighbourhood gradients in obesity and mental health problems. By contrast, modest genetic selection/concentration was evident for teen pregnancy and poor educational outcomes, suggesting that neighbourhood effects for these outcomes should be interpreted with care.

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Published In

Nature human behaviour

DOI

EISSN

2397-3374

ISSN

2397-3374

Publication Date

June 2019

Volume

3

Issue

6

Start / End Page

576 / 586

Related Subject Headings

  • Young Adult
  • Wales
  • United States
  • Socioeconomic Factors
  • Schizophrenia
  • Risk Assessment
  • Residence Characteristics
  • Pregnancy in Adolescence
  • Pregnancy
  • Obesity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Belsky, D. W., Caspi, A., Arseneault, L., Corcoran, D. L., Domingue, B. W., Harris, K. M., … Odgers, C. L. (2019). Genetics and the geography of health, behaviour and attainment. Nature Human Behaviour, 3(6), 576–586. https://doi.org/10.1038/s41562-019-0562-1
Belsky, Daniel W., Avshalom Caspi, Louise Arseneault, David L. Corcoran, Benjamin W. Domingue, Kathleen Mullan Harris, Renate M. Houts, et al. “Genetics and the geography of health, behaviour and attainment.Nature Human Behaviour 3, no. 6 (June 2019): 576–86. https://doi.org/10.1038/s41562-019-0562-1.
Belsky DW, Caspi A, Arseneault L, Corcoran DL, Domingue BW, Harris KM, et al. Genetics and the geography of health, behaviour and attainment. Nature human behaviour. 2019 Jun;3(6):576–86.
Belsky, Daniel W., et al. “Genetics and the geography of health, behaviour and attainment.Nature Human Behaviour, vol. 3, no. 6, June 2019, pp. 576–86. Epmc, doi:10.1038/s41562-019-0562-1.
Belsky DW, Caspi A, Arseneault L, Corcoran DL, Domingue BW, Harris KM, Houts RM, Mill JS, Moffitt TE, Prinz J, Sugden K, Wertz J, Williams B, Odgers CL. Genetics and the geography of health, behaviour and attainment. Nature human behaviour. 2019 Jun;3(6):576–586.

Published In

Nature human behaviour

DOI

EISSN

2397-3374

ISSN

2397-3374

Publication Date

June 2019

Volume

3

Issue

6

Start / End Page

576 / 586

Related Subject Headings

  • Young Adult
  • Wales
  • United States
  • Socioeconomic Factors
  • Schizophrenia
  • Risk Assessment
  • Residence Characteristics
  • Pregnancy in Adolescence
  • Pregnancy
  • Obesity