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Allogeneic Committed Hematopoietic Progenitors Are Protective Against Radiation.

Publication ,  Conference
Chen, BJ; Deoliveira, D; Chao, NJ
Published in: Blood
November 16, 2007

Whole-body irradiation may lead to bone marrow failure and death. It was previously reported that congenic myeloerythroid-restricted progenitors are able to radioprotect lethally irradiated animals. However, this approach will not be practical because syngeneic/congenic donors are rarely available in humans. To solve this problem, we investigated whether allogeneic committed progenitors are also radioprotective. Hematopoietic committed progenitors were isolated by FACS based on the presence of early progenitor marker CD244 and the absence of stem cell marker CD150 (CD244+CD150−). BALB/c mice (H2d) were lethally irradiated with 8.5 Gy. Within 4 hours of irradiation, the irradiated mice were infused with 5x105 sorted hematopoietic progenitors from major histocompatibility complex mistmatched C57BL/6 donors (H2b). As shown in the Figure B, all the mice in the radiation control group died within 15 days post irradiation (median survival time: 13 days). Infusion of hematopoietic committed progenitors significantly prolonged the survival of the lethally irradiated mice (P=0.0018, median survival time: 28 days). These results are similar to the results obtained from congenic hematopoietic progenitors using 1x105 cells (Figure A, P<0.0001, median survival time: 10 days vs. 28 days). These data suggest that allogeneic hematopoietic committed progenitor cells are also able to mediate radioprotective effects. Similar to the congenic hematopoietic committed progenitors, allogeneic progenitors may also exert radioprotective effects by jumpstarting hematologic recovery post irradiation. These cells may be stockpiled and used as “off-the-shelf” products for radiation injury and other applications.Figure Figure

Duke Scholars

Published In

Blood

DOI

EISSN

1528-0020

ISSN

0006-4971

Publication Date

November 16, 2007

Volume

110

Issue

11

Start / End Page

4871 / 4871

Publisher

American Society of Hematology

Related Subject Headings

  • Immunology
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, B. J., Deoliveira, D., & Chao, N. J. (2007). Allogeneic Committed Hematopoietic Progenitors Are Protective Against Radiation. In Blood (Vol. 110, pp. 4871–4871). American Society of Hematology. https://doi.org/10.1182/blood.v110.11.4871.4871
Chen, Benny J., Divino Deoliveira, and Nelson J. Chao. “Allogeneic Committed Hematopoietic Progenitors Are Protective Against Radiation.” In Blood, 110:4871–4871. American Society of Hematology, 2007. https://doi.org/10.1182/blood.v110.11.4871.4871.
Chen BJ, Deoliveira D, Chao NJ. Allogeneic Committed Hematopoietic Progenitors Are Protective Against Radiation. In: Blood. American Society of Hematology; 2007. p. 4871–4871.
Chen, Benny J., et al. “Allogeneic Committed Hematopoietic Progenitors Are Protective Against Radiation.Blood, vol. 110, no. 11, American Society of Hematology, 2007, pp. 4871–4871. Crossref, doi:10.1182/blood.v110.11.4871.4871.
Chen BJ, Deoliveira D, Chao NJ. Allogeneic Committed Hematopoietic Progenitors Are Protective Against Radiation. Blood. American Society of Hematology; 2007. p. 4871–4871.

Published In

Blood

DOI

EISSN

1528-0020

ISSN

0006-4971

Publication Date

November 16, 2007

Volume

110

Issue

11

Start / End Page

4871 / 4871

Publisher

American Society of Hematology

Related Subject Headings

  • Immunology
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology
  • 3101 Biochemistry and cell biology
  • 1114 Paediatrics and Reproductive Medicine
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology